肠道微生物组在瘤发生和瘤治疗中的作用
Renuka Sri Sai Peddireddi1, Sai Kiran Kuchana2, Rohith Kode2
1Mansfield Kaseman Health Clinic, Rockville, MD 20850, USA.
Cancers
|January 10, 2026
概括
肠道微生物组影响癌症的发展和治疗反应. 通过饮食或益生菌调节肠道细菌可能会改善癌症护理和结果.
科学领域:
- 微生物学和瘤学
- 肠道微生物组在癌症病原和治疗中的作用
背景情况:
- 肠道微生物组是人类健康的关键调节者,影响新陈代谢,免疫力和癌症.
- 微生物失生症与通过炎症,基因毒性代谢产物,改变胆酸代谢和损害表皮屏障完整性的瘤发生有关.
- 肠道微生物组显著影响宿主对癌症治疗的反应,包括化疗,放射治疗和免疫治疗.
研究的目的:
- 综合目前关于肠道微生物组在癌症发展 (瘤发生) 和治疗 (瘤疗法) 中的双重作用的证据.
- 专注于13种具有强烈临床相关性和与微生物组有机联系的特定癌症.
- 提供机械洞察力和微生物组与癌症结局之间的临床相关性.
主要方法:
- 审查当前的科学文献和证据.
- 根据机理学数据,全球健康负担和转化潜力,专注于13种选择的癌症.
- 在瘤发生和治疗调节中分析常见的微生物机制.
主要成果:
- 微生物失生症通过促进炎症,产生基因毒性代谢物和改变代谢途径,促进癌症.
- 特定的肠道细菌和微生物多样性会影响癌症治疗的疗效和毒性,特别是免疫疗法.
- 像Faecalibacterium prausnitzii和Akkermansia muciniphila这样的有益微生物可以增强抗瘤免疫力和对免疫检查点抑制剂的反应.
结论:
- 肠道微生物组是癌症的重要驱动因素,也是治疗成功的可修改因素.
- 整合微生物组分析和调制策略 (饮食,益生菌,便微生物群移植) 是个性化癌症护理的前景.
- 未来的瘤实践可能包括基于微生物组的干预措施,以改善患者的治疗结果.
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