任何年龄段的高剂量甲甲酸盐:来自欧洲HDMTX注册表的安全性,有效性和结果
Bertrand Pourroy1, Maria D Aumente2, Christian Koenecke3
1Oncopharma Unit, Hôpitaux Universitaires de Marseille La Timone, 13005 Marseille, France.
Cancers
|January 10, 2026
概括
高剂量的甲状腺素 (HDMTX) 可以导致癌症患者的延迟排泄 (DME) 和急性损伤 (AKI). 对于早期检测和管理这些毒性,对甲状腺酸盐水平的仔细监测至关重要.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
背景情况:
- 高剂量甲基酸盐 (HDMTX) 是各种癌症的重要化疗剂.
- 延迟甲状腺除 (DME) 和急性损伤 (AKI) 是HDMTX的潜在毒性.
- 了解DME和AKI的发生率和结果对于优化HDMTX治疗至关重要.
研究的目的:
- 在接受HDMTX的患者中确定DME和AKI的发病率.
- 调查DME,AKI和临床结果之间的关联.
- 确定影响DME和AKI发生的因素.
主要方法:
- 来自HDMTX欧洲注册表的2501个HDMTX课程的回顾性分析.
- 包括来自5个欧洲国家的12个机构的数据.
- 使用奇平方和威尔科克森等级和和测试来评估关联的统计分析.
主要成果:
- DME发生在12.1%的课程中,AKI发生在15.4%的课程中.
- 在初级中枢神经系统淋巴瘤 (PCNSL) 和非霍奇金淋巴瘤 (NHL) 过程中观察到最多的DME发病率.
- 在急性淋巴细胞白血病 (ALL) 过程中观察到AKI的最高发病率.
- DME与治疗延迟,更长的住院时间和剂量修改有关.
结论:
- HDMTX是有效的,但可以导致AKI和DME.
- 没有可靠地确定AKI和DME的预测因素.
- 密切监测甲铁酸盐水平对于管理HDMTX诱导的毒性至关重要.
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