新辅助化学免疫治疗与新辅助化学放射治疗在可切除食道癌症的三年结果:一个多中心回顾性研究
Shilong Deng1,2, Xue Yan1, Ying Peng3
1Department of Radiotherapy, Fuzong Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou 350025, China.
Cancers
|January 10, 2026
概括
与新辅助化学免疫疗法 (nCRT) 相比,新辅助化学免疫疗法 (nCIT) 显著改善了局部晚期食道状细胞癌 (LA-ESCC) 患者的生存率. 对于特定的患者亚组,nCRT可能更好.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 医学瘤学 医学瘤学
背景情况:
- 局部发达的食道状细胞癌 (LA-ESCC) 在手术后呈现出不良预后.
- 新辅助治疗,如化疗免疫疗法 (nCIT) 和化疗放射疗法 (nCRT) 正在探索改善结果.
- 这些新辅助策略的长期疗效需要进一步研究.
研究的目的:
- 为了比较新辅助化学免疫疗法 (nCIT) 与新辅助化学辐射疗法 (nCRT) 在LA-ESCC患者的长期疗效.
- 为了评估两组治疗之间的整体存活率 (OS),客观反应率 (ORR) 和无病存活率 (DFS).
- 确定可能从nCIT或nCRT中获益更多的患者子组.
主要方法:
- 对来自中国的225名LA-ESCC患者 (2015-2024) 的多中心追溯分析.
- 患者接受了nCIT或nCRT,然后进行手术.
- 倾向性得分匹配用于平衡nCIT和nCRT组之间的基线特征.
主要成果:
- 与nCIT相比,新辅助化学辐射疗法 (nCRT) 的ORR,T/N降级和病理完整响应 (pCR) 率较高.
- 新辅助化疗免疫疗法 (nCIT) 显示出优异的3年总生存率 (OS) 和无病生存率 (DFS).
- 亚组分析表明,对于N+或非cT4疾病的患者,nCRT可能更有效.
结论:
- 新辅助化疗免疫疗法 (nCIT) 为LA-ESCC患者提供了显著的生存优势.
- 新辅助化学放射治疗 (nCRT) 可能是特定患者群体 (N+或非cT4) 的首选选择.
- 需要进一步的随机对照试验来证实这些发现并指导治疗决策.
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