烟草使用对口腔癌查算法性能的影响
Elyse Kanagandram1, Aksel Alp1, Thair Takesh1
1Beckman Laser Institute, University of California Irvine School of Medicine, Irvine, CA 92612, USA.
Cancers
|January 10, 2026
概括
口腔癌查的准确性因吸烟类型而异. 该平台在大多数用户中显示出高灵敏度,但特异性不同,突出显示需要为各种烟草习惯量身定制选算法.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 公共卫生 公共卫生
背景情况:
- 有效的口腔癌 (OC) 查对于早期诊断和改善患者的治疗结果至关重要.
- 当前查方法的不准确性可能导致检测延迟.
- 烟草使用可以改变口腔粘膜,可能会影响查准确度,并掩盖智能查工具中的其他风险因素.
研究的目的:
- 评估基于成像和风险因素的口腔癌查平台的查准确度.
- 评估平台在不同类型的烟草使用中的表现.
主要方法:
- 318名先前有阳性口腔癌风险查的受试者被按烟草使用情况分类 (吸烟者,电子烟者,者,水使用者,多次使用者,非使用者).
- 一个原型的OC查平台记录了人口统计数据,风险因素,临床检查结果,AFI和pWLI.
- 该平台的OC风险评估与口腔医学专家的评估进行了比较.
主要成果:
- 查平台在吸烟者,电子烟者,多种产品使用者,者和水使用者中表现出高灵敏度 (>90%),非使用者的灵敏度为80%.
- 与烟草使用者相比,非使用者的特异性更高,具有显著的差异 (例如,在者中为33.3%,在vapers中为55.6%,在吸烟者中为62.5%).
- 平台和专家评价之间的总体一致性超过了80%;在非用户和用户之间发现了显著的准确性差异 (p <0.05),除了vapers.
结论:
- 吸烟类型显著影响口腔癌查方法的有效性.
- 将与烟草使用类型相关的变量集成到基于成像和风险因素的算法中,对于改善OC查至关重要.
- 根据个人的吸烟习惯量身定制查策略,可以提高诊断准确度和患者的治疗结果.
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