70岁以上的质母细胞瘤患者的生存预测因素:依赖时间的多变量分析
Ahmad M S Ali1,2, Viraj Parmar1, Cathal J Hannan1
1Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool L9 7LJ, UK.
Cancers
|January 10, 2026
概括
对于年长的质母细胞瘤患者 (≥70岁),辅助疗法和总切除显著提高了生存率. 吸烟与更糟糕的结果有关,而化学放射治疗的益处在手术后的早期是最强的.
科学领域:
- 神经外科 神经外科
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
背景情况:
- 质母细胞瘤 (GB) 的预后不好,特别是在老年人中.
- 全球人口老龄化意味着更多的老年患者将面临GB.
- 在这个人口群体中确定生存预测因素至关重要.
研究的目的:
- 为了确定70岁及以上的质母细胞瘤患者的生存预测因素.
- 专注于手术切除,辅助疗法和并发症的影响.
- 评估影响老年GB患者结果的因素.
主要方法:
- 对124名接受GB手术的患者 (≥70岁) 的回顾性审查.
- 对人口统计,KPS,CCI,瘤特征,切除程度和辅助治疗的分析.
- 卡普兰-梅尔曲线和考克斯回归用于生存分析.
主要成果:
- 辅助化学放射治疗和总体切除 (GTR) 独立预测了改善的生存率.
- 吸烟与死亡风险增加有关.
- 辅助疗法的生存益处在术后早期最为明显,并且随着时间的推移而减少.
结论:
- 辅助疗法和GTR是老年质母细胞瘤患者的关键生存预测因素.
- 吸烟会对这个年龄组的结果产生负面影响.
- 早期,积极的多式疗法,包括辅助疗法,为老年GB患者提供生存益处.
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