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纳米银暴露对氧化应激,转录组和Procambarus clarkii肠道微生物群的影响

Jian Li¹, Bin Qiu¹, Yitian Chen¹

¹Engineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education Ministry, Hunan Normal University, Changsha 410081, China.

|January 10, 2026

概括

纳米银暴露会对鱼组织造成重大损害,改变氧化应激标志物和肠道微生物群. 这项研究强调了纳米银在养殖中的潜在风险.

科学领域:

水生物质毒理学研究
环境科学环境科学
甲动物生物学甲动物生物学

背景情况:

我们对纳米银对的毒性了解有限.
纳米银的使用越来越多,需要进行毒性评估.

研究的目的:

评估暴露于纳米银的类的体系病理变化,氧化应激,转录学和肠道微生物群的变化.
确定纳米银对肌肉,肝和的影响.

主要方法:

对鱼组织的组织病理学检查.
对氧化应激生物标志物的测量 (CAT,SOD,GSH,MDA).
转录组分析和肠道微生物群的分析.

主要成果:

纳米银诱导了渐进的肌肉纤维损伤,肝胰腺扩大和状组织障碍.
改变了氧化应激标志物和增加了马隆迪甲水平.
肠道微生物群多样性的变化,与增加的Bacteroides和Ca_Bacilloplasma,和减少的Citrobacter,导致炎症.
转录组分析显示,分别在肌肉和肝中分别有1549和1305个差异表达的基因,PPAR信号通路受到显著影响.

结论:

纳米银对鱼健康构成重大风险,影响多个器官系统.
氧化应激和肠道微生物群的变化表明有毒反应.
这些发现对于评估纳米银在水产养殖环境中的安全性至关重要.

关键词:

这是一种Procambarus clarkii.我们的肠道微生物群.纳米银的使用方法氧化应激是一种氧化应激.转录组 (transcriptome) 是一个转录组.

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