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微炎症驱动的基因表达动力学在代谢障碍和癌症的发病过程中

Marian Elisa Gabrielle T Cadungog^1,2, Lemmuel L Tayo³

¹School of Chemical, Biological, and Materials Engineering and Sciences, Mapúa University, Manila 1002, Philippines.

|January 10, 2026

概括

微炎症通过共享的分子通路将代谢疾病和癌症联系在一起. 这项研究确定了保存的RNA处理和蛋白质稳定签名作为关键驱动因素,提供了新的治疗点.

科学领域:

分子生物学分子生物学
基因组学就是基因组学.
在瘤学瘤学.

背景情况:

微炎症是连接代谢疾病和癌症的关键因素.
这些条件背后的共同分子机制仍然不完全理解.

研究的目的:

在代谢疾病和癌症中识别炎症介导病理的常见分子驱动因素.
探索RNA处理和蛋白质稳定在这些相互关联的疾病中的作用.

主要方法:

从易怒肠综合征 (IBS),肥胖,2型糖尿病 (T2D),结直肠癌 (CRC),细胞癌 (RCC) 和胰腺癌 (PC) 的基因表达特征的整合.
权重基因共同表达网络分析 (WGCNA) 以确定保存的基因模块和枢纽基因.
调节性微RNA (miRNA) 和它们的网络相互作用的分析.

主要成果:

鉴定了三个高度保存的基因模块 (蓝色,棕色,绿色),在RNA处理,结合体组装,核糖体生物发生和蛋白质稳定中得到丰富.
关键的枢纽基因和调节性miRNAs形成相互连接的网络,调节转录,mRNA成熟,蛋白质合成和炎症信号.
炎症似乎通过RNA处理和蛋白质稳定中断的间接调节,可能受到肠道微生物群和代谢状态的影响.

结论:

保存的分子特征将微炎症,代谢性疾病和瘤发生联系起来.
RNA调节,蛋白质稳定和miRNA介导的控制是潜在的诊断和治疗目标.

关键词:

处理RNA处理RNA的过程癌症代谢性疾病相互作用炎症代谢交叉通话交叉通话代谢重编程是指代谢重编程.微RNAs 是一个微型RNA.微炎症是一种微炎症.蛋白质稳定性蛋白质稳定性核糖体生物发生的生物生成.拼接一个osomeome.

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