Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

18.8K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
18.8K
LTR Retrotransposons03:08

LTR Retrotransposons

19.4K
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
19.4K
DNA-only Transposons02:57

DNA-only Transposons

17.1K
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
17.1K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.6K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.6K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

4.0K
4.0K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

13.1K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The Rlign algorithm for enhanced electrocardiogram analysis through heart rate-corrected ECG alignment for explainable classification and clustering.

European heart journal. Digital health·2026
Same author

Response to 'promising advances and remaining challenges in AI-driven QTc estimation' by Zekai Yu.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

Variable partition of non-homogeneous ooplasm sets the stage for divergent potency of 2-cell stage blastomeres.

Molecular human reproduction·2026
Same author

End-to-End Platform for Electrocardiogram Analysis and Model Fine-Tuning: Development and Validation Study.

Journal of medical Internet research·2026
Same author

Catch-Up Weight Gain and Gut Microbiota Development in Full-Term Small for Gestational Age Children During the First Year of Life-A Prospective Cohort Study.

American journal of human biology : the official journal of the Human Biology Council·2026
Same author

Recombination landscape shaped by inversion polymorphisms: a high-density linkage map and chromosome-level assembly of inversion-rich spruce bark beetle genome.

G3 (Bethesda, Md.)·2026
Same journal

Spatial Heterogeneity of Phytoplankton Taxa and Functional Groups Under Multidimensional Environmental Factors in Karst Urban Rivers.

Biology·2026
Same journal

Paleopathology of a Lower Miocene Carettochelyid Turtle from the Moghra Formation, Egypt.

Biology·2026
Same journal

Effects of Type I Diabetes Mellitus and Masticatory Loading on Mandibular Growth in Growing Rats: A Longitudinal CBCT Study.

Biology·2026
Same journal

Data-Limited Stock Status Assessment of Bonga Shad, <i>Ethmalosa fimbriata</i> (Bowdich, 1825) and Lesser African Threadfin, <i>Galeoides decadactylus</i> (Bloch, 1795) in the Central Gulf of Guinea.

Biology·2026
Same journal

Gonadogenesis in the Bearded Dragon (<i>Pogona vitticeps</i>, Agamidae): A Comprehensive Histological Analysis from Gonadal Ridge Formation to Testicular and Ovarian Development.

Biology·2026
Same journal

The Programmable Microbiome: Integrative AI and Multi-Omics Frameworks for Precision T2DM Management.

Biology·2026
查看所有相关文章

相关实验视频

Updated: Jan 13, 2026

Real-Time Quantification of the Effects of IS200/IS605 Family-Associated TnpB on Transposon Activity
04:04

Real-Time Quantification of the Effects of IS200/IS605 Family-Associated TnpB on Transposon Activity

Published on: January 20, 2023

2.8K

可转换元件共识序列的基于变压器的分类与TEclass2的共识序列

Lucas Bickmann1, Matias Rodriguez2, Xiaoyi Jiang1

  • 1Department of Computer Science, University of Münster, 48149 Münster, Germany.

Biology
|January 10, 2026
PubMed
概括
此摘要是机器生成的。

可转移元素 (TE) 是基因组进化的关键,但很难分类. 新的软件TEclass2使用深度学习进行精确的TE分类,帮助基因组研究.

关键词:
在TE分类中,分类是TE.生物信息学网络工具深度学习是一种深度学习.变压器架构的架构可转移的元素可以转移.

更多相关视频

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
09:30

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

9.9K
Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a Burkholderia gladioli Symbiont of Lagria villosa Beetles
09:55

Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a Burkholderia gladioli Symbiont of Lagria villosa Beetles

Published on: August 12, 2021

4.2K

相关实验视频

Last Updated: Jan 13, 2026

Real-Time Quantification of the Effects of IS200/IS605 Family-Associated TnpB on Transposon Activity
04:04

Real-Time Quantification of the Effects of IS200/IS605 Family-Associated TnpB on Transposon Activity

Published on: January 20, 2023

2.8K
Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
09:30

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

9.9K
Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a Burkholderia gladioli Symbiont of Lagria villosa Beetles
09:55

Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a Burkholderia gladioli Symbiont of Lagria villosa Beetles

Published on: August 12, 2021

4.2K

科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 可转移元素 (TE) 在真核基因组中丰富,对基因组进化至关重要.
  • TE序列的复杂性质挑战了准确的分类和基因组分析.
  • 目前的TE分类工具在可靠性和范围上存在局限性.

研究的目的:

  • 开发一种新,准确和可靠的软件工具,用于分类可转换元素 (TE) 共识序列.
  • 通过解决TE识别方面的挑战,提高基因组注释的效率和准确性.
  • 为 TE 分类提供灵活的平台,可适应自定义数据集.

主要方法:

  • 开发了TEclass2,这是一种使用深度学习方法的软件工具.
  • 采用线性变压器架构,采用k-mer令牌化和特定序列的调整.
  • 实施了针对定制 TE 数据集的灵活模型培训功能.

主要成果:

  • TEclass2实现了 TE共识序列的更好的分类性能,将其分为16个超级家族.
  • 与现有的TE分类工具相比,该软件显示出更高的可靠性.
  • 使用预训练模型的Web界面可用于快速的TE分类.

结论:

  • TEclass2在可转换元素的准确和快速分类方面取得了重大进展.
  • 该工具提高了基因组注释的准确性,并支持进一步的生物信息学研究.
  • TEclass2提供了一个强大的解决方案,用于分析真核生物基因组中TE的复杂景观.