热处理的Limosilactobacillus fermentumPS150改善睡眠质量,具有严重程度依赖的益处:一个随机的,安慰剂控制的试验
Mon-Chien Lee1,2, Chao-Yuan Chen1,3, Ching-Yun Chen1
1Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 333325, Taiwan.
Nutrients
|January 10, 2026
概括
热处理的Limosilactobacillus fermentum (HT-PS150) 可能通过增强黑激素和稳定清醒来改善睡眠. 在患有严重失眠和焦虑症状的个体中,益处最明显.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 失眠是一种常见的睡眠障碍,长期安全治疗选择有限.
- 微生物群-肠-大脑轴影响黑激素和下丘脑-垂体-上腺 (HPA) 调节.
- 临床前研究表明,Limosilactobacillus fermentum PS150可能会影响睡眠调节.
研究的目的:
- 为了评估热处理配方 (HT-PS150) 在改善睡眠的成年人睡眠不良的疗效.
- 评估HT-PS150对内分泌和昼夜节律标记物的影响.
- 探索睡眠相关生物标志物和症状负担的调节.
主要方法:
- 一个随机,双盲,安慰剂对照试验,涉及84名睡眠不良的成年人.
- 参与者接受了安慰剂或HT-PS150治疗八周.
- 结果包括患者报告的睡眠,焦虑,抑郁,生活质量,动图和生物标志物 (黑激素,皮质醇,素).
主要成果:
- 在整个队列中的组之间,初级睡眠结果尺度 (PSQI,ISI) 没有显著差异.
- 探索性分析显示,HT-PS150增加了夜间黑激素的调节,改善了白天的素水平.
- 亚组分析显示,在具有更高基线失眠严重程度的参与者中,HT-PS150对睡眠质量 (PSQI) 和焦虑 (GAD-7) 的改善更大.
结论:
- HT-PS150通过增强黑激素和减弱HPA轴活性来调节睡眠-清醒调节的潜力.
- 该干预措施在稳定清醒和为更有症状的个体提供临床益处方面表现有希望.
- 进一步的研究可能会验证HT-PS150对于经历严重失眠和焦虑的特定人群的有效性.
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