超越生物化学标记:在COVID-19中表征营养不良
Katarzyna Plewka-Barcik1, Maria Różańska-Trzepla2, Krzysztof Kłos1
1Department of Internal Medicine, Infectious Diseases and Allergology, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland.
Nutrients
|January 10, 2026
概括
营养状况下降在住院的2019年冠状病毒病 (COVID-19) 患者中很常见,主要影响脂肪组织. 标准营养不良标志物不存在,表明异常呈现,挑战传统评估工具.
科学领域:
- 临床营养学 临床营养学
- 传染性疾病 传染性疾病
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 在住院患者中,营养不良很普遍,病情恶化,特别是在COVID-19中.
- 在COVID-19中,炎症和代谢干扰加快了营养下降.
- 早期检测标志物对于住院COVID-19患者的干预至关重要.
研究的目的:
- 在COVID-19住院期间调查生化和身体成分变化.
- 确定医院获得的营养状况障碍的主要特征.
- 评估COVID-19患者的营养状况变化.
主要方法:
- 前性,单中心的观察性研究.
- 66名患者因COVID-19住院治疗.
- 生物化学标志物和体质组成在入院和出院时测量.
主要成果:
- 30%的患者经历了营养恶化 (体重减轻>3%).
- 恶化与男性性别和更长的住院时间有关.
- 减肥主要涉及脂肪组织;瘦肉质量保持稳定.
- 没有观察到传统的营养不良标志物 (低蛋白,前蛋白,胆固醇).
结论:
- 住院的COVID-19患者面临着显著的营养恶化.
- 在COVID-19中的营养下降呈现出不典型的,具有挑战性的标准评估工具.
- 有效的早期检测需要考虑非传统标记物.
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