抵抗训练和乳清蛋白对MASLD患者在卡路里限制下骨肌肉质量和功能的独立和联合影响
Chae-Been Kim1,2, Jinwoo Sung1, Dohyun Ahn1,3
1Department of Sport Science, Pusan National University, Busan 46241, Republic of Korea.
Nutrients
|January 10, 2026
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 的卡路里限制可以通过足够的蛋白质来保持肌肉质量. 然而,将抵抗训练和乳清蛋白结合起来,由于严重的卡路里不足,并没有增强肌肉功能.
科学领域:
- 运动生理学 运动生理学
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 管理通常涉及热量限制 (CR),这可能会对肌肉健康产生负面影响.
- 抵抗训练和乳清蛋白补充剂的有效性,独立或联合,以抵消在MASLD中大量CR期间的肌肉损失,尚未得到充分理解.
研究的目的:
- 研究抗力训练和乳清蛋白补充剂对MASLD患有显著卡路里限制的成年人身体组成和肌肉功能的影响.
主要方法:
- 一项为期4周的随机双盲试验,涉及45名患有MASLD的成年人,CR约为30%以下.
- 参与者被分配到四组:用乳清蛋白进行抵抗训练 (E-PRO),用安慰剂进行抵抗训练 (E-PLA),仅用乳清蛋白 (PRO) 或仅用安慰剂 (PLA).
- 蛋白质摄入量在0.8和1.5g·kg-1·day-1之间变化,运动组每周训练5天.
主要成果:
- 所有组都实现了显著的体重和脂肪质量减轻,而没有损失骨肌肉质量,身体组成没有显著的群体间差异.
- 与安慰剂相比,抵抗训练组 (E-PRO,E-PLA) 在各种肌肉组的峰值扭矩和总工作中表现出改善.
- 单独补充乳清蛋白 (PRO) 提供了一些功能性改善,但联合干预 (E-PRO) 没有显示出与单独抵抗训练相比的协同效益,这可能是由于严重的能量赤字.
结论:
- 适当的蛋白质摄入量 (≥0.8 g·kg−1·day−1) 是足够的,以保持骨肌肉质量在MASLD患者经历严重的热量限制.
- 为了功能性适应,将抵抗训练和乳清蛋白结合在一起的潜在合成代谢益处可能会因该人群的实质性能量赤字而减弱.
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