免疫性思维:连接饮食模式,微生物群和心理健康
Giuseppe Marano1,2, Gianandrea Traversi3, Osvaldo Mazza4
1Department of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.
Nutrients
|January 10, 2026
概括
采用地中海饮食,减少超加工食品 (UPF) 和使用精神生物药物可以帮助管理抑郁症症状. 这些饮食策略影响肠-大脑轴和免疫系统,补充了标准的精神病治疗.
科学领域:
- 营养精神病学 营养精神病学
- 肠-大脑轴研究研究
- 微生物组科学 微生物组科学
背景情况:
- 饮食模式显著影响肠-大脑轴和免疫信号传递.
- 这些相互作用对心理健康状况如抑郁和焦虑有影响.
- 最近的证据 (2020-2025) 探讨了饮食干预,超加工食品 (UPF) 暴露和精神病菌.
研究的目的:
- 综合了最近关于地中海式饮食,UPF暴露和精神病药物对精神病的临床影响的证据.
- 整合与临床实践相关的关于肠-大脑轴和免疫信号的机制性见解.
- 专注于临床上有意义的结果,如抑郁症症状严重程度和诊断.
主要方法:
- 从2020年1月到2025年10月搜索的主要数据库 (PubMed/MEDLINE,Scopus,Web of Science) 进行了搜索.
- 包括随机对照试验 (RCT),前性队列,以及报告成人临床精神病结果的系统性审查/元分析.
- 优先考虑高质量的定量综合和最近的RCT,并对提取的数据进行叙事综合.
主要成果:
- 地中海饮食 (MD) 干预措施在减少抑郁症状方面表现有前途,尽管需要大规模的RCT.
- 过度加工食品 (UPF) 的高摄入量始终与精神障碍和抑郁症的风险增加有关.
- 精神病菌剂 (益生菌/益生菌) 对抑郁症状提供小到中等的益处,有效性有所变化.
结论:
- 地中海式饮食,减少UPF摄入量和向性精神病菌药物可以补充抑郁症的标准精神病治疗.
- 机制涉及微生物群代谢物 (例如短链脂肪酸) 和免疫-炎症通路.
- 未来的研究需要强大的RCT,标准化协议和微生物群分层,以确定响应者和阐明机制.
相关概念视频
Psychoneuroimmunology: Cardiovascular Disease
382
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
382
Irritable Bowel Syndrome I: Introduction
910
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
910
Psychoneuroimmunology: Diabetes and Cancer
432
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
432
Assessment of the Gastrointestinal System II: Health Perception Pattern
443
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
443
Anatomy of the Intestines
86.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.7K
Human Genetics
1.4K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.4K


