间歇性禁食和益生菌用于2型糖尿病中肠道微生物群调节:叙述性审查
Zhiwen Zhang1, Shaokang Wang1, Guiju Sun1
1Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.
Nutrients
|January 10, 2026
概括
间歇性禁食 (IF) 和益生菌通过对肠道细菌产生积极影响,显示出对管理2型糖尿病的前景. 结合这些策略可能会带来协同效益,但需要更多的研究来证实有效性.
科学领域:
- 微生物学 微生物学
- 代谢过程中的代谢.
- 内分泌学 在内分泌学.
背景情况:
- 2型糖尿病 (T2DM) 是一种与肠道失调,炎症和葡萄糖控制不良相关的全球健康危机.
- 间歇性禁食 (IF) 和益生菌独立地改善T2DM中的血糖控制,主要是通过微生物群调节.
- 了解它们的结合微生物群依赖机制对于T2DM管理至关重要.
研究的目的:
- 审查和综合关于T2DM中IF和益生菌的微生物群依赖机制的证据.
- 评估结合IF和T2DM的益生菌的生物学理由和初步数据.
- 识别知识缺口和未来的研究方向.
主要方法:
- 在T2DM中对IF (时间限制的食, 5:2) 和多菌株益生菌进行临床前和临床研究的综合文献综述.
- 机械路径,微生物转移和代谢结果的定性合成.
- 专注于重叠的信号通路:SCFA,胆酸,GLP-1和肠道屏障功能.
主要成果:
- IF增强了Akkermansia muciniphila和Faecalibacterium prausnitzii,恢复了微生物节奏,并增加了SCFA/胆酸的产生.
- 多菌株益生菌适度降低HbA1c和禁食葡萄糖.
- 这两种干预措施都降低了内毒性,并改善了肠道完整性;观察到临床前协同作用,但人类数据有限.
结论:
- IF和益生菌共享重叠的微生物群介导途径,有利于T2DM.
- 作为辅助策略的联合使用在生物学上是合理的.
- 需要进行大规模随机试验,深度研究和临床终点,以确认协同效应.
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