一年内未能达到70%的建议蛋白质摄入量,预测胃切除术后的13倍高的死亡率
Jou-Huai Lin1, Shao-Ciao Luo2, Li-Chun Liu1
1Department of Food and Nutrition, Taichung Veterans General Hospital, Taichung City 40705, Taiwan.
Nutrients
|January 10, 2026
概括
在胃切除术后获得足够的蛋白质摄入量可以显著改善存活率. 无法达到70%蛋白质摄入量的患者死亡风险增加了13倍,突出显示了手术后需要营养支持的需要.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 外科手术的结果
背景情况:
- 胃癌在东亚是一个重要的健康问题.
- 胃切除术是主要的治疗方法,但手术后的营养不良,特别是低蛋白摄入量,会使患者的结果恶化.
- 胃切除术后蛋白质摄入不足与较差的生存率有关.
研究的目的:
- 评估胃切除术后一年达到至少70%的建议蛋白质摄入量与三年生存率之间的关联.
- 为了确定胃切除术后蛋白质摄入不足的危险因素.
- 确定蛋白质摄入量对胃癌患者整体生存时间的影响.
主要方法:
- 对65名胃癌患者进行胃切除术的前性,单中心的观察性研究.
- 蛋白质摄入达到率 (PIAR) 计算在手术后12个月.
- 患者分为PIAR ≥70%和<70%的分层组.
- 使用时间到事件方法分析的总生存率,随访时间中位数为2.1年.
主要成果:
- 7名患者 (10.8%) 在12个月内未能达到PIAR≥70%.
- 不足够的蛋白质摄入与更高的全胃切除率 (71.4%与19.0%) 和晚期疾病 (III-IV阶段:85.7%与39.7%) 相关.
- 蛋白质摄入量不足的患者的生存率明显降低 (危险比率:13.02).
结论:
- 胃切除术后一年未能达到≥70%的建议蛋白质摄入量是死亡率的强有力的独立预测因素.
- 摄入不够的蛋白质会使死亡风险增加13倍.
- 营养监测和早期干预至关重要,特别是对于全胃切除术或晚期胃癌患者.
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