怀孕期间的饮食胆摄入量和中国人口中的先天性心脏缺陷
Yue-Hua Li1, Ziqi Xiao1, Rui Guo1
1Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Nutrients
|January 10, 2026
概括
怀孕期间母亲的胆摄入量较高与先天性心脏缺陷 (CHD) 的风险降低有关. 促进饮食中的胆可能有助于预防新生儿的心血管疾病.
科学领域:
- 营养流行病学 营养流行病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 公共卫生 营养 公共卫生 营养
背景情况:
- 母亲胆摄入量与先天性心脏缺陷 (CHD) 之间的关系尚未得到充分证实.
- 在怀孕期间调查食胆及其衍生物对心脏病风险的影响对于母婴健康至关重要.
研究的目的:
- 检查怀孕期间母亲饮食中摄入的胆及其代谢物与心血管疾病发生之间的关联.
- 为预防心血管疾病的潜在营养策略提供证据.
主要方法:
- 一项病例控制研究,涉及中国西北地区474例冠心病和948例对照病例.
- 在怀孕期间使用经过验证的食物频率调查问卷评估的饮食摄入量.
- 混合后勤回归模型用于分析胆摄入量与心脏病风险之间的关联.
主要成果:
- 增加总胆和特定胆衍生物 (甲,甲,甘氨酸胆,胆) 的摄入量显著与总心脏病,心室隔膜缺陷和心房隔膜缺陷的风险降低有关.
- 总胆摄入量的最高三位数显示,总心脏病风险降低了62% (OR:0.38,95% CI:0.24-0.61).
- 反向关联在各种母亲特征中是一致的,在城市人口中更为明显.
结论:
- 怀孕期间母亲饮食中较高的胆摄入量可能是预防心脏病的保护因素.
- 鼓励孕妇摄入胆可能是预防胎儿心血管疾病的有效策略.
- 需要进一步的研究和公共卫生倡议,重点关注孕产妇的胆营养.
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