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极度早产婴儿的学龄神经发育和亚托皮结果:单抗三菌株双杆菌随机对照试验的后续研究
Gayatri Athalye-Jape1,2, Chandra Rath1,2,3, Meera Esvaran4
1Neonatology, King Edward Memorial Hospital, Child and Adolescent Health Service, Perth, WA 6008, Australia.
Nutrients
|January 10, 2026
概括
短期单菌株和三菌株Bifidobacterium益生菌在极度早产婴儿中显示出可比的安全性和长期神经发育,生长和形结局. 这两种益生菌配方都适合这种脆弱人群.
科学领域:
- 新生儿医学 新生儿医学
- 发育儿科 发育儿科
- 微生物组研究 微生物组研究
背景情况:
- 益生菌补充剂在非常早产婴儿中很常见,但长期的神经发育,生长和形结局需要评估.
- 此前,SiMPro试验评估了单菌株 (SS) 与三菌株 (TS) Bifidobacterium益生菌对极度早产婴儿的短期影响.
研究的目的:
- 评估短期益生菌补充后极度早产婴儿的5年神经发育,生长和血压结果.
- 评估在接受SS或TS益生菌的婴儿中,学龄的亚托皮相关结果.
主要方法:
- 从SiMPro随机试验中对婴儿进行的后续研究评估了5岁时的神经发育 (认知,行为,执行功能),生长和血压.
- 在六到七年后,使用ISAAC问卷评估了与亚托邦相关的结果.
- 使用线性混合模型分析了纵向结果,使用后勤回归模型建模了损伤指标.
主要成果:
- 神经发育结果,包括严重损伤 (FSIQ <70),生长,BMI和血压,在SS和TS益生菌组之间是可比的.
- 执行功能,残疾率和与相关的结果也显示,两组之间没有显著差异.
- 在这两组中,随访率都很高 (SS: 89.2% vs TS: 95%).
结论:
- 单菌株和三菌株Bifidobacterium益生菌配方对极度早产婴儿是安全的.
- 这些益生菌干预导致了同样的神经发育,生长和学校年龄的形相关的结果.
关键词:
这种细菌是Bifidobacterium.亚托皮亚托皮亚 亚托皮亚是什么意思极端的过早生育时间.肠道大脑轴 肠道大脑轴神经行为神经行为.神经发育的神经发育预产期前的时间.益生菌益生菌是一种益生菌.更多相关视频
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