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用于预测2型糖尿病中心脏代谢风险的肠道透性生物标志物

Nursel Dal¹, Saniye Bilici², Sirin Akin³

¹Department of Nutrition and Dietetics, Faculty of Health Sciences, Bandirma Onyedi Eylul University, Balikesir 10250, Türkiye.

|January 10, 2026

概括

在2型糖尿病中,肠道透性标记物如 zonulin 和 I-FABP 与炎症和脂质相关,但不能直接预测心血管风险. 腹部肥胖与这些患者心血管风险更高有关.

科学领域:

内分泌学和新陈代谢学
胃肠病学胃肠病学
心血管疾病研究研究

背景情况:

糖尿病,特别是2型糖尿病 (T2DM),是心血管疾病 (CVR) 的重要危险因素.
过高血糖和肠道损伤是将T2DM与增加的CVR联系起来的机制.
评估肠道透性生物标志物可能为T2DM患者的CVR预测提供新的见解.

研究的目的:

评估各种肠道透性生物标志物的实用性,以预测T2DM患者的CVR.
探索肠道透性标记物,炎症标记物和脂质概况之间的相关性.

主要方法:

2024年的一项研究包括70名T2DM患者 (19-64岁).
收集的数据包括社会人口统计,健康状况,弗雷明汉风险评分 (FRS),人体测量和血清葡萄糖水平,HbA1c,脂质,CRP,TNF-α,IL-6,三甲基胺-N-氧化物 (TMAO),佐努林和肠脂肪酸结合蛋白 (I-FABP).
计算了内脏脂肪指数 (VAI) 和血性腺素指数 (PAI).

主要成果:

18.5%的患者根据FRS.有一个中高的CVR.
在BMI,腰高度比,身体脂肪比,VAI和FRS得分之间观察到正相关性.
血清TMAO,佐努林和I-FABP水平在低风险和中高风险组之间没有显著差异.
TMAO,佐努林和I-FABP与炎症标志物 (TNF-α,IL-6) 和甘油三酸具有积极的相关性.
佐努林和I-FABP也与PAI有积极的相关性.

结论:

腹部肥胖和肠道透性受损可能会影响T2DM的炎症过程和血液脂质概况.
虽然在这个队列中不是直接的预测因素,但肠道透性标志物显示与炎症和脂质的关联.
需要进一步的大规模研究,以调查影响T2DM肠道透性和心脏代谢风险之间的关系的饮食因素.

关键词:

在I-FABP中使用.心血管疾病的风险.糖尿病糖尿病患者糖尿病患者肠道的通透性肠道的通透性三甲基胺N-氧化物这里是 zonulin zonulin 的位置.

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