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关于临床上先进的PROTAC降解剂及其合成的最新情况

Ranjan Kumar Acharyya1, Yugandhar Kothapalli2, Suresh Yarlagadda3

  • 1Rogel Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Molecules (Basel, Switzerland)
|January 10, 2026
PubMed
概括

化向化体 (PROTACs) 提供了一种新的治疗方法,通过利用细胞的自然处置系统降解向蛋白质. 这篇综述强调了PROTACs的进展,临床开发和分子设计的进展到试验.

关键词:
抗癌药物 抗癌药物 抗癌药物癌症 癌症 癌症 癌症 癌症蛋白质溶解向的嵌合体 (PROTACs) 是一个目标蛋白质降解 (TPD)

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