用UHPLC-MS/MS使用磁性固相提取与同位素标记的内部标准对化品中的残留性激素进行有针对性的确定
Yalei Dong1, Shuyan Sun1,2, Yasen Qiao1
1National Institutes for Food and Drug Control/NMPA Key Laboratory for Research and Evaluation of Cosmetics, Beijing 100050, China.
Molecules (Basel, Switzerland)
|January 10, 2026
概括
一种使用磁性固相提取 (MSPE) 和超高性能液态染色体质谱法 (UHPLC-MS/MS) 的新方法可以准确检测化品中的微量性激素. 这项分析显示,在116种测试的化品中,10种化品中存在激素污染.
科学领域:
- 分析化学 分析化学
- 环境健康 环境健康
- 化品科学 化品科学
背景情况:
- 化品存在安全问题,原因是性激素等潜在的危险成分.
- 长时间暴露在化品中的微量性激素可能会导致严重的健康损害.
研究的目的:
- 开发和验证一种可靠的方法,用于检测化品中的微量性激素.
- 评估与化品中的残留激素相关的安全风险.
主要方法:
- 超高性能液态色谱-质谱学 (UHPLC-MS/MS) 与磁性固相提取 (MSPE) 结合.
- 使用同位素标记的内部标准 (IL-ISs) 来提高准确性和精度.
- 系统地调查样品预处理,色谱学和质谱学参数.
主要成果:
- 开发的MSPE-UHPLC-MS/MS方法表现出高效率和精度,恢复率在71.7-116.2%之间,相对标准偏差 (RSD) 从1.6%到8.3%.
- 在116个分析的化品样本中,在10个样本中检测到微量孕激素和雌激素.
- 该方法在AGREE指标上获得了0.66的绿色配置分数.
结论:
- 与UHPLC-MS/MS和IL-IS相结合的MSPE是一种方便,高效和可行的技术,用于检测复杂的化品矩阵中的遗留性激素.
- 预先的安全评估表明,某些预防脱发的化品中的残留孕激素存在潜在的健康风险.
- 经过验证的方法提供了一个可靠的工具,以确保化品产品的安全性和合规性.
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