在类风湿性关节炎中长度比较calprotectin和C-反应蛋白:在三种向治疗中实践证据
Angelo Fassio1, Isotta Galvagni1, Silvia Sartoris2,3
1Rheumatology Unit, University of Verona, 37126 Verona, Italy.
Diagnostics (Basel, Switzerland)
|January 10, 2026
概括
血清calprotectin和C-反应蛋白 (CRP) 水平随着类风湿性关节炎 (RA) 治疗而降低. 卡尔蛋白蛋白在预测缓解方面表现有前途,特别是与TNFα和JAK抑制剂.
科学领域:
- 类风湿病学 类风湿病学
- 临床免疫学临床免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 血清calprotectin是类风湿性关节炎 (RA) 中炎症的潜在生物标志物.
- 在不同向的RA疗法之间进行纵向calprotectin比较的现实世界数据有限.
- 了解生物标志物动态对于优化RA管理至关重要.
研究的目的:
- 为了评估 RA 患者的血清蛋白和 C-反应蛋白 (CRP) 动态.
- 为了评估calprotectin和CRP在阿达利穆马布,阿帕达西提尼布和托西利祖马布治疗下的缓解预测能力.
- 为了比较calprotectin与CRP在不同RA治疗小组中预测缓解的性能.
主要方法:
- 在RA患者开始服用阿达利木马布,阿帕达西提尼布或托西利祖马布的回顾性队列研究.
- 血清calprotectin和CRP在基线,3个月和6个月测量.
- 通过DAS28和CDAI评估的疾病活动;用于缓解预测的ROC分析.
主要成果:
- 随着时间的推移,观察到血清calprotectin,CRP和DAS28的显著降低 (p < 0.001).
- 总体而言,CRP在预测缓解方面表现优于calprotectin (AUC为0.739比0.636).
- 在阿达利马布/乌帕达西提尼布组中,calprotectin显著优于CRP (AUC为0.929对比0.857),而在托西马布组中,表现相似.
结论:
- 在RA中,血清calprotectin水平显著降低治疗后的启动.
- 与CRP相比,calprotectin在TNFα和JAK抑制下显示出更好的缓解预测.
- 蛋白作为一种有价值的,对治疗敏感的生物标志物,可能在RA监测中补充CRP,特别是当CRP可靠性受到影响时.
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