生物基性与化学AgNPs:抗微生物功效和稳定性的比较
Mukil Madhusudanan1, Ivan Mijakovic1,2, Priyanka Singh1
1The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.
International journal of molecular sciences
|January 10, 2026
概括
使用植物提取物和细菌超浮剂的银纳米颗粒 (AgNPs) 的绿色合成,与化学方法相比,显示出优越的抗菌活性. 这些环保方法为AgNP生产提供了一个可持续的替代方案,具有增强的生物特性.
科学领域:
- 纳米技术和材料科学 材料科学
- 微生物学与传染病的研究
- 绿色化学和生物技术的发展
背景情况:
- 银纳米粒子 (AgNPs) 具有显著的抗微生物特性,使其在各种应用中具有价值.
- 传统的AgNP化学合成可能涉及危险的试剂和环境问题.
- 生物灵感合成方法为环保和经济高效的AgNP生产提供了潜力.
研究的目的:
- 为了比较通过植物提取物,细菌超标和化学减少合成的AgNP的抗菌疗效.
- 通过使用UV-Vis光谱,TEM和DLS的不同方法生产的AgNP的特征.
- 评估AgNP与增强生物活性可持续合成路径的潜力.
主要方法:
- 使用Crassula ovata (玉) 叶提取物,Bacillus licheniformis细菌超和三酸盐合成AgNP.
- 使用UV-Vis光谱,传输电子显微镜 (TEM) 和动态光散射 (DLS) 进行AgNP的表征.
- 通过确定最小杀菌度 (MBC) 来测试对大肠杆菌, Pseudomonas aeruginosa, Staphylococcus epidermidis 和耐美西林黄金杆菌 (MRSA) 的抗菌活性.
主要成果:
- 与化学合成的AgNP相比,使用植物和细菌超浮剂合成的AgNP对所有测试病原体的MBC值显著较低.
- 植物提取物衍生的AgNP显示MBCs范围为10-15μg/mL,而细菌超级生物衍生的AgNP范围为7.5-12.5μg/mL.
- 酸盐减少的AgNP显示MBCs显著更高,范围在40-80μg/mL之间,这表明抗菌作用力较低.
结论:
- 使用植物提取物和细菌上游剂的AgNP的环保合成,与传统化学方法相比,产生更高的抗菌活性.
- 这些绿色合成途径是生产具有增强生物效能的AgNP的可行和可持续的替代方案.
- 这些发现支持植物和细菌超介导AgNP在医疗和制药领域的应用.
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