缺血症和心房动之间的相关性:有什么新鲜事?
Beatrice Marinacci1, Noemi Mencarelli1, Giorgia Stornelli1,2
1Department of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
International journal of molecular sciences
|January 10, 2026
概括
肠道微生物群失调可能会增加心房动 (AF) 的风险. 通过饮食或补充剂改变肠道健康可能是一个有前途的AF预防策略,但需要更多的研究.
科学领域:
- 心脏病学 心脏病学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 心房动 (AF) 是一种普遍存在的心律失常症,影响全球2~4%的成年人,预计患病率将翻一番.
- 肠道微生物群失生症越来越被认为是AF发展的潜在风险因素.
- 了解肠道健康和AF之间的联系对于开发新型治疗策略至关重要.
研究的目的:
- 审查当前关于肠道微生物群失调和心房动之间的关联的证据.
- 探索拟议的机制,微生物因素和参与AF病变的代谢物.
- 突出临床影响,并确定当前研究中的差距.
主要方法:
- 对最近研究肠道微生物群-AF轴的文献综述.
- 分析拟议的致病机制,将失生症与AF联系起来.
- 合成有关微生物基因,代谢物和临床发现的数据.
主要成果:
- 肠道微生物群的变化 - - 失生症 (dysbiosis) 与AF的风险增加有关.
- 特定的微生物变化和代谢物与AF的发展有关.
- 饮食干预,益生菌和益生菌显示出AF预防和治疗的潜力.
结论:
- 肠道微生物群失调是一种可修改的AF风险因素.
- 准肠道活化可能为AF管理提供了一个有前途的途径.
- 进一步的前性研究对于阐明机制和确认临床疗效至关重要.
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