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scANMF:在scRNA-seq中准确的细胞类型注释之前的知识和图形规则化的NMF

Weilai Chi1, Ying Zheng1, Huaying Fang2,3

  • 1School of Mathematical Sciences, Capital Normal University, Beijing 100048, China.

International journal of molecular sciences
|January 10, 2026
PubMed
概括

在单细胞RNA测序 (scRNA-seq) 中精确的细胞类型注释得到了 scANMF 的改进,这是一个集成多种数据类型的新型框架. 这种强大的方法提高了注释准确度,即使先前的生物信息有限或杂.

关键词:
单元格类型的注释图表规范化的图表非负矩阵因子化的非负矩阵因子化.之前的知识整合.对噪声的强度对噪声的强度半监督学习 半监督学习一个单细胞RNA测序.

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RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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