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炎症作为心血管代谢综合征的预后标志物:系统性审查
Sihle E Mabhida1, Haskly Mokoena2, Mamakase G Sello3,4
1Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, Cape Town 7505, South Africa.
International journal of molecular sciences
|January 10, 2026
概括
系统性炎症与心血管 - - 代谢综合征 (CKMS) 的预后密切相关. 像SIRI和SII这样的炎症生物标志物在CKMS患者中显示出与增加的死亡率和疾病进展的一致关联.
科学领域:
- 心血管--代谢综合征 (CKMS) 研究研究
- 炎症生物标志物分析分析
- 预测标记的识别和预测标记的识别
背景情况:
- 心血管--代谢综合征 (CKMS) 涉及相互关联的心血管,和代谢疾病.
- 系统性炎症越来越被认为是CKMS病原和预后的关键因素.
- 最近CKMS的运行需要更新的证据综合.
研究的目的:
- 系统地审查和综合有关CKMS患者炎症生物标志物的预后价值的证据.
- 识别经常评估的炎症标志物及其与CKMS结果的关联.
- 突出系统性炎症在CKMS预后中的作用.
主要方法:
- 在主要生物医学数据库 (PubMed,Embase,CINAHL,Web of Science,Scopus) 系统搜索2024年1月1日至2025年6月30日发表的研究.
- 包括纵向队列和横截面研究,评估CKMS成年人的炎症标志物和预后结果.
- 由于异质性的叙述合成;使用预后研究质量 (QUIPS) 工具评估偏差风险.
主要成果:
- 纳入了13项涉及282,016名参与者的研究;其中5项是横截面研究.
- 经常评估的生物标志物包括SIRI,SII,hs-CRP/HDL-C比率,DII和TyG指数.
- 这些炎症标志物水平的升高始终与较高的死亡风险,CKMS进展和不良代谢结果有关.
结论:
- 系统性炎症是与CKMS预后相关的关键标志物.
- 炎症生物标志物显示出产生假设的潜力,但需要标准化和外部验证才能获得临床效用.
- 这些发现代表了早期信号,需要在不同的环境中复制,并进行进一步的纵向/干预研究.
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