肺癌中的内微生物群:TME调节和免疫疗法反应中的新兴作用
Xue Yang1, Liyuan Yin1, Zhuoying Tian1
1Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu 610041, China.
International journal of molecular sciences
|January 10, 2026
概括
内微生物群通过调节瘤免疫微环境 (TIME) 显著影响肺癌免疫疗法. 了解这些微生物为改善治疗反应和克服耐药性提供了新的策略.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 内微生物群越来越被认为是瘤免疫微环境 (TIME) 中的关键参与者.
- 这些微生物影响患者对癌症免疫疗法的反应,特别是在肺癌中.
- 它们的作用不仅仅是被动存在,而是积极调节抗瘤免疫力.
研究的目的:
- 审查内微生物群在肺癌免疫治疗反应中的作用.
- 阐明微生物影响瘤免疫微环境 (TIME) 的机制.
- 探索针对微生物群的策略,以克服免疫疗法耐药性.
主要方法:
- 使用PubMed和Web of Science进行了叙事文献综述.
- 从创立到2025年11月,搜索了英语文章.
- 对内微生物群,时间和免疫检查点抑制剂 (ICI) 治疗结果的综合证据.
主要成果:
- 内微生物,代谢物和囊泡显著影响时间和ICI疗效.
- 微生物特征显示出作为免疫治疗反应的预测生物标志物的潜力.
- 有证据表明,特定的微生物群组成与肺癌患者的治疗结果有关.
结论:
- 内微生物群是肺癌免疫治疗的关键调节器.
- 向瘤内微生物群是一个有希望的策略,以提高治疗疗效.
- 对微生物相互作用的进一步研究可以指导基于微生物群的精密疗法.
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