通过Artemisia indica的代谢和抗氧化剂调节威尔德. 在葡萄糖和胆固醇调节失调中的水性提取物
Chiao-Yun Tseng1, Yueching Wong1, Charng-Cherng Chyau2
1Department of Nutrition, Chung Shan Medical University, Taichung City 40201, Taiwan.
International journal of molecular sciences
|January 10, 2026
概括
亚特米西亚印第卡水性提取物 (AAE) 通过减少氧化应激和改善代谢平衡,有助于控制血糖和胆固醇. 这种传统的草药显示出作为代谢障碍的天然治疗剂的希望.
科学领域:
- 药理学 药理学是指药理学的学科.
- 代谢研究研究 代谢研究
- 植物化学 植物化学
背景情况:
- 阿尔特梅西亚印尼卡威尔德. 是一种具有已知的生物活性的传统草药.
- 血糖失调和脂质失调是重要的代谢健康问题.
- 识别用于新陈代谢调节的自然剂是至关重要的.
研究的目的:
- 为了评估Artemisia indica的作用,Willd. 水性提取物 (AAE) 在失糖症和失脂症.
- 阐明AAE代谢作用的潜在机制.
- 确定AAE.的主要活性成分.
主要方法:
- 通过HPLC-ESI-MS/MS分析识别活性化合物.
- 一种高脂肪饮食和链毒素诱导的代谢障碍小鼠模型 (BALB/cByJNarl).
- 评估葡萄糖水平,果糖胺,氧化应激标志物,脂质代谢调节剂 (SREBP-1,FAS),聚醇通路和抗氧化酶.
主要成果:
- 氨酸显著降低了空腹血糖和果糖胺水平.
- 通过恢复抗氧化酶活动和抑制多路径,AAE改善了氧化应激.
- 通过调节SREBP-1和FAS表达,AAE减少了脂质积累,并降低了PKC-α和NF-κB表达.
结论:
- 亚特米西亚印加水性提取物 (AAE) 有效调节葡萄糖和胆固醇代谢.
- AAE显示出减轻氧化应激和改善整体代谢平衡的潜力.
- AAE支持其作为代谢障碍的天然草药治疗剂的使用.
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