甲基供体在癌症发展中的双边性质,从预防到进展
Da Pan1, Shaokang Wang1, Guiju Sun1
1Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.
International journal of molecular sciences
|January 10, 2026
概括
甲基供体营养素对于单碳代谢至关重要. 它们在癌症中的作用是复杂的,在早期起着保护作用,但可能会在以后促进瘤生长,这取决于背景.
科学领域:
- 营养生物化学 营养生物化学
- 癌症生物学 癌症生物学
- 基因组稳定性 基因组稳定性
背景情况:
- 甲基捐赠营养素 (叶酸盐,B12,B6,胆,贝他因,甲) 对于单碳代谢,DNA甲基化和核酸合成至关重要.
- 甲基捐赠者与癌症之间的关系是矛盾的,由于依赖晚期流行病学数据,经常被误解.
- 甲基捐赠体在致癌的早期和晚期影响是不同的,需要细致的理解.
研究的目的:
- 综合证据证明甲基捐赠体在癌症发展中的双重作用.
- 提出一个取决于背景的框架,以了解甲基供体对癌症的影响.
- 为癌症预防和管理指导精准营养策略.
主要方法:
- 机械学研究的审查和综合.
- 对癌前病变的研究进行分析.
- 对早期致癌模型的检查.
主要成果:
- 充分的甲基供体可用性可以防止早期癌症的发展.
- 在已确定的癌症中,甲基捐赠者可以被瘤细胞利用来促进增殖和进展.
- 甲基捐赠者的影响取决于环境,受时间,代谢状态和组织生物学的影响.
结论:
- 甲基捐赠者在癌症中并非具有均的保护性或有害性.
- 建议重新理解甲基捐赠体作为依赖上下文的修饰剂.
- 这种转变可以促进精准营养的癌症预防和向抑制.
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