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Updated: Jun 7, 2026

Investigating Receptor-ligand Systems of the Cellulosome with AFM-based Single-molecule Force Spectroscopy
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通过高速原子力显微镜可视化P-糖蛋白的功能动力学及其由Elacridar调制

Yui Kanaoka1, Norie Hamaguchi-Suzuki2, Yuto Nonaka1

  • 1Department of Physics, Graduate School of Science, Nagoya University, Furo-Cho, Chikusa-Ku, Nagoya 464-8602, Aichi, Japan.

International journal of molecular sciences
|January 10, 2026
PubMed
概括

视觉化了P-glycoprotein (P-gp) 的动态,揭示了ATP稳定了它的结构. 埃拉克里达尔 (Elacridar) 是一种药物.

关键词:
这是一种P-glycoprotein蛋白.高速原子力显微镜技术单分子动力学的动力学

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相关概念视频

Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...