Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Associations between dual sensory impairments and the new-onset cardiometabolic multimorbidity among middle-aged and older adults: the mediating role of frailty.

Experimental gerontology·2026
Same author

Nutritional Components and Anti-Alcoholic Liver Disease Activity of Selenium-Enriched <i>Agaricus subrufescens</i>.

Foods (Basel, Switzerland)·2026
Same author

Extraintestinal Manifestations of Inflammatory Bowel Disease: A Focus on Kidney Complications.

International journal of molecular sciences·2026
Same author

Anti-inflammatory flavan alkaloids from the bulbs of Hymenocallis littoralis (Jacq.) Salisb.

Phytochemistry·2026
Same author

Photoinduced HCl-catalyzed acylation of N-heterocycles.

Chemical communications (Cambridge, England)·2026
Same author

Non-persistent environmental chemical mixture and gestational hypertension, blood pressure, and blood pressure trajectories during pregnancy.

Environment international·2026

相关实验视频

Updated: Jan 13, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

40.1K

对于动脉样硬化的动物模型.

Linghong Zeng1, Jingshu Chi2, Meiqi Zhu1

  • 1Department of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China, Hengyang 421001, China.

International journal of molecular sciences
|January 10, 2026
PubMed
概括
此摘要是机器生成的。

选择合适的动物模型对于研究动脉样硬化至关重要. 像老鼠,老鼠和仓鼠这样的动物为了解心血管疾病机制和开发新疗法提供了不同的优势.

关键词:
动脉样硬化 动脉样硬化脱脂血症是什么情况高脂肪和胆固醇饮食高脂肪和胆固醇饮食动物模型动物模型

更多相关视频

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

14.4K
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.0K

相关实验视频

Last Updated: Jan 13, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

40.1K
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

14.4K
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.0K

科学领域:

  • 心血管研究研究心血管研究
  • 疾病的动物模型.
  • 动脉样硬化病原体的产生

背景情况:

  • 动脉样硬化是心血管疾病的主要原因,涉及脂质不良,炎症和斑块发育.
  • 动物模型对于研究动脉样硬化病原和测试治疗方法至关重要.
  • 动物模型具有成本效益和可复制性,但具有特定物种的脂质代谢差异.

研究的目的:

  • 系统地审查用于动脉样硬化研究的动物模型选择.
  • 在动物模型中分析性别和年龄对动脉样硬化发展的影响.
  • 为了比较小鼠,老鼠和仓鼠在动脉样硬化研究的不同阶段的适用性.

主要方法:

  • 对常用的动物菌株的审查:C57BL/6J小鼠,斯普拉格-道利老鼠,威斯塔老鼠和金色仓鼠.
  • 专注于倾向于动脉样硬化的背景 (Apoe-/-或Ldlr-/-).
  • 在模型选择中考虑饮食,性别,年龄和脂质代谢 (HDL,LDL,CETP).

主要成果:

  • 由于高胆固醇和生存的原因,在晚期斑块稳定性研究中优先选择Apoe-/-或Ldlr-/-背景的雄性C57BL/6J小鼠.
  • 鼠 (SD,Wistar) 显示动脉样硬化进展较慢,适合用于早期疾病机制研究.
  • 哈姆斯特提供类似人类的脂质代谢,但具有可变性和有限的病变进展,影响繁殖能力.

结论:

  • 对于动脉样硬化研究的动物模型选择必须考虑特定物种的脂质代谢和疾病进展特征.
  • 小鼠适合进行先进的斑块研究,而老鼠和仓鼠更适合进行早期机制和人模仿性脂质研究.
  • 考虑到性别,年龄和遗传背景的仔细优化对于动脉样硬化研究的翻译相关性至关重要.