关于微生物组在脑质瘤中的作用的新兴见解:对最近证据的系统审查
Piotr Dubiński1,2, Martyna Odzimek-Rajska1, Sebastian Podlewski2
1Doctoral School, The Jan Kochanowski University, Żeromskiego 5, 25-369 Kielce, Poland.
International journal of molecular sciences
|January 10, 2026
概括
肠道微生物群影响大脑瘤的生长,特定的细菌与质瘤的进展或保护有关. 了解这些肠-大脑轴相互作用对于开发新的微生物组向疗法至关重要.
科学领域:
- 神经瘤学神经瘤学
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
背景情况:
- 质瘤,包括多形质母细胞瘤,是具有不良预后的侵袭性脑瘤.
- 人们越来越认识到肠道微生物群通过免疫,代谢和神经化学途径对癌症进展的影响.
研究的目的:
- 系统地审查最近关于肠道和内微生物群在质瘤生物学中的作用的证据.
- 在脑瘤进展的背景下,对肠-大脑轴的发现进行综合.
主要方法:
- 按照PRISMA 2020指南进行系统审查.
- 在主要的生物医学数据库中搜索了过去五年内同行评审的研究.
- 包括人类队列,动物模型和门德尔的随机化研究.
主要成果:
- 质瘤与肠道失生症有关,包括改变的Firmicutes:Bacteroidetes比率和Akkermansia丰富.
- 微生物代谢物,如短链脂肪酸和神经递质被改变,影响神经炎症和免疫抑制.
- 内细菌 (Fusobacteriota,Proteobacteria) 可能促进瘤生长,而某些有益细菌表现出保护性关联.
结论:
- 肠道微生物群失生症通过各种机制促进质瘤的进展.
- 需要使用标准化模型和多组学进行进一步的研究,以阐明因果关系,并开发基于微生物组的质瘤疗法.
相关概念视频
01:22Introduction to the Human Microbiota
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
01:22Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...