相关实验视频

Updated: Jan 13, 2026

Compost Microcosms as Microbially Diverse, Natural-like Environments for Microbiome Research in Caenorhabditis elegans

Compost Microcosms as Microbially Diverse, Natural-like Environments for Microbiome Research in Caenorhabditis elegans

Published on: September 13, 2022

PP_925:基因组缩小,最小化的新陈代谢,以及进化洞察力,使得微生物多样化

Peter V Evseev¹, Irina V Podoprigora², Andrei V Chaplin¹

¹Pirogov Russian National Research Medical University, Ostrovityanova Street 1, Moscow 117997, Russia.

International journal of molecular sciences

|January 10, 2026

概括

Bulleidia extructa菌株PP_925,是一种带有牙周炎的细菌,具有紧的基因组,代谢减少,但保留了关键的主机相互作用系统. 这表明了适应性灵活性和与相关的细菌血统共享的祖先.

科学领域:

微生物学微生物学
基因组学就是基因组学.
细菌病原体的产生

背景情况:

Bulleidia extructa菌株PP_925从牙周炎患者的牙周口袋中分离出来.
这种格拉姆阳性Bacillota表现出一个异常紧的基因组1.38 Mb.

研究的目的:

为了对Bulleidia extructa PP_925.925进行遗传学分析.
描述这种细菌的代谢谱和基因组特征.
研究它的进化关系和适应策略.

主要方法:

进行了家族遗传学分析,以确定PP_925.25的家族遗传位置.
使用比较基因组学分析基因组并确定关键系统.
进行了代谢途径重建和基因含量分析.

主要成果:

遗传学分析将PP_925置于与Solobacterium和Lactimicrobium密切相关的Erysipelotrichales中,并确定了新的分类.
该基因组显示显著减少,缺乏TCA循环和大多数de novo生物合成途径,表明依赖于救援和交叉养.
PP_925保留了祖先的格拉姆阳性细胞壁,并拥有宿主相互作用 (IV型 pili,粘附因子) 和防御 (CRISPR-Cas II-A,限制修饰) 的系统.

结论:

Bulleidia extructa PP_925 显示了大量的基因组缩小,同时保留了重要的宿主相互作用和防御机制.
遗传学数据表明,相关的血统中存在独立的甘损失,突出了进化灵活性.
比较基因组学揭示了一个小的核心基因组,具有可适应的谱系特定模块,表明最近的共同祖先和适应性进化.

关键词:

巴西洛塔 (Bacillota) 是一种类植物.布莱利迪亚斯 (Bulleidia) 是一个字体的群体.这种植物是 Bulleidia extructa.布莱迪亚提取物 PP_92525 提取物艾瑞西佩洛特里卡家族 (Erysipelotrichaceae) 是一个植物.埃里西比洛特里卡莱斯 (Erysipelotrichales) 是一种的植物.埃里西佩洛特里奇亚是什么意思埃里西佩洛特里奇亚的演化过程埃里西佩洛特里奇亚的基因组学埃里西佩洛特里希亚的新陈代谢埃里西佩洛特里奇亚原产地埃里西佩洛特里奇亚 pangenome 的一个.的菌体Erysipelotrichia是一种菌体.埃里西佩洛特里奇亚的分类学菌质的进化已经开始了.基因组的缩小是基因组的缩小.

更多相关视频

Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution

Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution

Published on: June 14, 2024

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

相关概念视频

Bacterial Phylum Firmicutes

Bacterial Phylum Firmicutes

Firmicutes is a diverse phylum of Gram-positive bacteria characterized by a low GC content in their genomes. This phylum includes organisms with monoderm or diderm cell envelopes, highlighting a complex evolutionary history. Firmicutes comprises several major orders, including Lactobacillales, Clostridiales, and Bacillales, which exhibit remarkable diversity in their morphology, metabolism, and ecological roles.The order Lactobacillales includes lactic acid bacteria, which are fermentative...

Microbial Nutrition

Microbial Nutrition

Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...

Bacterial Phylum Tenericutes

Bacterial Phylum Tenericutes

The phylum Tenericutes, which includes the single class Mollicutes, comprises bacteria that lack cell walls. The term "Mollicutes" derives from the Latin word mollis, meaning "soft." These organisms are among the smallest known and are commonly referred to as mycoplasmas due to the prominence of the genus Mycoplasma, which includes well-known human pathogens. Despite their inability to stain gram-positively (a result of their lack of cell walls), mycoplasmas are phylogenetically related to the...

Modern Molecular Taxonomy

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

Applications of Molecular Taxonomy

Applications of Molecular Taxonomy

Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...

Bacterial Phylum Bacteroidota

Bacterial Phylum Bacteroidota

The phylum Bacteroidota includes over 700 species classified into four primary orders: Bacteroidales, Cytophagales, Flavobacteriales, and Sphingobacteriales. These gram-negative, non-sporulating rods exhibit saccharolytic capabilities and can be aerobic or fermentative, encompassing obligate aerobes, facultative aerobes, and obligate anaerobes. Many species display gliding motility, though some are nonmotile or use flagella. The genus Bacteroides is well-studied due to its significant role in...