由Dicarboxyl-bis-pillar[5]arene/CTAB形成的水分散的超分子纳米颗粒 主机-客户互动作为奎尔丁有效的输送系统
Marco Milone1, Martina Mazzaferro1,2, Antonella Calderaro1
1Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli Studi di Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
International journal of molecular sciences
|January 10, 2026
概括
超分子纳米颗粒 (SNPs) 是使用二甲二柱[5]arene和CTAB开发的,用于封装Quercetin. 这些稳定的SNP增强抗氧化活性,并保护细胞免受氧化应激.
科学领域:
- 超分子化学 超分子化学
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 水溶性较差的药物通常具有有限的生物可用性.
- 超分子纳米粒子 (SNPs) 可以改善药物输送.
- 柱状是分子封装的有效宿主.
研究的目的:
- 开发水溶解的超分子纳米粒子 (SNPs) 来增强药物输送.
- 为了研究在CTAB/H SNPs.内囊素 (Q) 的封装.
- 评估开发的纳米粒子的抗氧化和细胞保护性质.
主要方法:
- 用于SNP制备的微乳液方法使用二甲二柱[5]烯 (H) 和 cetyltrimethylammonium化物 (CTAB).
- 动态光散射 (DLS) 用于尺寸和表面电荷分析.
- 核磁共振光谱 (1H,2D TOCSY,2D NOESY,DOSY) 和UV-Vis用于结构确认.
- 在体外测定 (DPPH,ABTS,FRAP) 抗氧化活性和基于细胞的测定用于细胞保护.
主要成果:
- 在CTAB/H纳米粒子 (大约. 40纳米大小,+15mV电荷) 显示高体稳定性 (>3个月).
- 结构分析证实CTAB被纳入柱状腔,形成稳定的组件.
- 素 (Q) 的封装成功,产生了CTAB/H/Q纳米粒子.
- 该系统表现出低细胞毒性和显著的抗氧化活性.
- 含有奎尔素的SNP增强了细胞吸收,并提供了对氧化应激的细胞保护.
结论:
- 稳定,水可分散的超分子纳米粒子 (SNPs) 已成功合成.
- 该CTAB/H系统有效地封装了水溶性较差的药物,如奎尔丁.
- 开发的SNP显示了增强药物输送,抗氧化疗法和细胞保护的潜力.
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