口腔疾病中的大麻素信号和自:分子机制和治疗影响
Undral Munkhsaikhan1, Md Ataur Rahman2, Alivia Shasteen1
1College of Dental Medicine, Lincoln Memorial University, 1705 St. Mary Street, Knoxville, TN 37917, USA.
International journal of molecular sciences
|January 10, 2026
概括
大麻素调节细胞循环过程的自,影响癌症和炎症等口腔疾病. 这种机制也显示出牙髓再生的前景,为牙科提供了新的治疗途径.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 自是一种基本的细胞过程,通过降解和循环来维持恒常状态.
- 大麻素信号影响细胞功能,包括自,对口腔健康有影响.
- 自失调与口腔疾病有关,例如口腔状细胞癌 (OSCC),牙周炎和牙炎.
研究的目的:
- 审查大麻素受体激活 (CB1,CB2) 和口腔组织中自道之间的分子相互作用.
- 探索CBD和THC等大麻素在调节自,炎症和亡中的作用.
- 评估大麻素调节自在牙纸再生和口腔疾病治疗中的潜力.
主要方法:
- 文献综述侧重于研究大麻素-自性交叉的实验研究.
- 分析大麻素 (CBD,THC) 如何影响关键的自调节器 (mTOR,AMPK,Beclin-1).
- 检查大麻素对细胞过程 (如炎症,亡和干细胞行为) 的影响.
主要成果:
- 大麻素调节自调节器,影响自流,炎症和亡.
- 大麻素抑制PI3K/AKT/mTOR通路,并促进ROS诱导的自.
- 大麻素诱导的自支持干细胞的生存和分化,表明牙纸再生的潜力.
- 大麻素在口腔组织中表现出双重的抗炎和抗癌特性.
结论:
- 大麻素信号传递在调节口腔组织内自方面发挥着重要作用.
- 大麻素诱导的自为口腔疾病和组织再生提供了潜在的治疗策略.
- 需要进一步的研究来解决诸如受体选择性,生物可用性和临床应用的监管问题等挑战.
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