在患有炎症性肠病的患者中评估乙型肝炎疫苗接种的免疫影响
Irene Soleto1, Alicia C Marin1,2, Montse Baldan-Martin1
1Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28006 Madrid, Spain.
患有炎症性肠病 (IBD) 的患者在接种疫苗后往往不会产生乙型肝炎免疫力. 这项研究表明,IBD患者的免疫反应受损是由于免疫失调和炎症的混合.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 患有炎症性肠病 (IBD) 的患者对乙型肝炎疫苗接种有较差的免疫反应.
- 标准和强化疫苗接种计划往往无法诱导IBD患者的保护性免疫力.
研究的目的:
- 调查IBD患者B型肝炎疫苗不响应背后的免疫机制.
- 确定不同的免疫特征,区分响应者与不响应者在IBD中接种乙型肝炎疫苗.
主要方法:
- 一项实验性观察性研究,涉及18名乙型肝炎病毒 (HBV) 血清阴性IBD患者,接受标准 Engerix-B® 疫苗接种.
- 对接种前和接种后收集的血液样本进行分析,以评估血清反应和免疫细胞概况.
- 根据血清学结果将患者分为响应者和不响应者.
主要成果:
- 响应者表现出增强的免疫激活,包括常规树突细胞1型,IgG等离子体,以及保存的B细胞和T细胞记忆.
- 非响应者表现出具有CCR2+单细胞丰富和更高基线调节性T细胞 (Treg) 频率的炎症性先天特征.
- 在非响应者中观察到自然杀手 (NK) 细胞激活受损和记忆潜力的丧失.
结论:
- 在IBD中B型肝炎疫苗失效是多因素的,涉及过度免疫调节,炎症增加和记忆潜力下降.
- 免疫反应受损的原因不是单一的途径,而是免疫失调的融合.
- 了解这些机制对于制定提高IBD患者疫苗疗效的策略至关重要.
相关概念视频
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...


