慢性病中的血短链脂肪酸和细胞因子概况:潜在的病理生理联系
Anna V Sokolova1, Dmitrii O Dragunov1, Grigory P Arutyunov1
1Department of Propaedeutics of Internal Diseases No. 1, Institute of Clinical Medicine, Federal State Autonomous Educational Institution of Higher Education 'N.I. Pirogov Russian National Research Medical University' of the Ministry of Health of the Russian Federation, 117513 Moscow, Russia.
International journal of molecular sciences
|January 10, 2026
概括
慢性病和心力衰竭患者的肉类与改变的身体组成,炎症和短链脂肪酸 (SCFA) 变化有关. 六酸和IL-8可能表明肌肉损失.
科学领域:
- 免疫代谢过程中的免疫代谢.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
背景情况:
- 在慢性病 (CKD) 和慢性心力衰竭 (CHF) 患者中,性是常见的.
- 这种人群中肌肉功能障碍的免疫代谢驱动因素尚未完全理解.
- 短链脂肪酸 (SCFA),细胞因子和身体成分变化是潜在的贡献者.
研究的目的:
- 调查CKD和CHF患者的萨尔科佩尼亚背后的免疫代谢机制.
- 为了确定这一群体中肉类的关键决定因素.
- 探索SCFA,炎症性细胞因子和身体成分与萨尔科佩尼亚的关联.
主要方法:
- 80名CKD和CHF患者的横截面研究.
- 综合性评估包括临床,生化,生物阻抗,炎症和SCFA分析.
- 统计分析:多变量后勤回归,LASSO,相关性,PCA,随机森林建模.
- 使用EWGSOP2标准诊断肉类症.
主要成果:
- 麻症的患病率为49% (39/80名参与者).
- 麻症患者的体脂百分比较低,尾骨肌 (ASM) 减少,步行速度较慢.
- 六酸 (C6) 与萨尔科佩尼亚 (OR=2.24) 有积极的相关性,而IL-8与萨尔科佩尼亚 (OR=0.38) 有相反的相关性.
- 观察到明显的SCFA-细胞因子模式,在C6-关联网络中进行亲炎性聚类.
- 综合模型显示出优异的歧视 (AUC=0.911).
结论:
- 在CKD-CHF患者中 Sarcopenia 是一种系统性免疫代谢障碍.
- 改变身体组成,炎症和失调的SCFA信号是关键特征.
- 六酸 (C6) 和IL-8可以作为肌肉衰退的生物标志物.
- 结果支持多维评估和有针对性的干预措施.
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