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Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
1.6K
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

1.4K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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相关实验视频

Updated: May 5, 2026

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
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Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

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在功能性便秘中依赖任务的皮质振荡动力学.

Jianhua Li1,2, Hui Yang3,4, Mingwei Xu5

  • 1Department of Rehabilitation Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.

Sensors (Basel, Switzerland)
|January 10, 2026
PubMed
概括
此摘要是机器生成的。

与健康个体相比,功能性便秘 (FC) 患者表现出不同的大脑活动模式. 这些脑肠轴功能的神经生理学差异可能会导致FC的新EEG生物标志物.

关键词:
大脑肠轴 脑肠轴皮层振荡的皮质振荡.电脑电图 (EEG) 是一种电脑电图.功能性便秘 功能性便秘

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Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
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Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG
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科学领域:

  • 神经科学是一个神经科学.
  • 胃肠病学 胃肠病学
  • 医疗成像医学成像

背景情况:

  • 功能性便秘 (FC) 是一种普遍存在的功能性胃肠道疾病.
  • 大脑-肠轴与FC病理生理学有关,但直接的神经生理学证据有限.

研究的目的:

  • 通过使用高密度电脑图 (EEG) 来研究FC患者和健康对照人群之间的神经生理差异.
  • 识别与FC相关的依赖任务的皮质活动模式.

主要方法:

  • 记录了来自21名FC患者和37名健康对照者的高密度EEG数据.
  • 分析了休息,认知和排便相关任务期间的大脑活动.
  • 检查了不同频段 (delta,theta,alpha,beta,gamma) 的区域和全球网络属性.

主要成果:

  • 与对照组相比,FC患者表现出独特的,取决于任务的EEG特征.
  • 具体的变化包括增加的α活动 (休息,排便任务),减少的时光 (排便任务) 和升高的时光 (认知任务).
  • 全球网络分析显示,在休息和排便任务期间,delta和beta频段的效率发生了变化.

结论:

  • 这些发现提供了直接的神经生理学证据,将皮质节律变化与FC联系起来.
  • 这项研究表明,脑肠轴功能障碍与FC症状产生有关.
  • 结果表明基于EEG的生物标志物和功能性便秘的神经调节疗法的潜力.