基于微针的技术,用于长期作用的穿皮药物输送到可穿戴设备中
Jiaxin Luo1, Yinqi Dai1, Xin Cheng1
1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Sensors (Basel, Switzerland)
|January 10, 2026
概括
本综述探讨了长期起作用的微针 (MN) 药物输送系统. 进展侧重于可生物降解的聚合物和持续释放的先进载体,但临床翻译面临着制造和安全方面的挑战.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 微针 (MNs) 为通过皮肤输送药物提供了一种最少的侵入性方法.
- 存在各种MN类型,包括固体,涂层,溶解,空洞,形成水凝和可生物降解.
- 持续的药物释放对于有效的长期治疗至关重要.
研究的目的:
- 系统地审查最近长期作用的基于微针的透皮药物输送系统的进展.
- 讨论持续药物释放的设计策略和材料平台.
- 确定阻碍临床翻译的挑战.
主要方法:
- 关于微针技术的最新科学出版物的文献综述.
- 基于其传递机制的微针类型的分类.
- 分析材料特性和药物载体的持续释放.
主要成果:
- 可生物降解的聚合物 (PLA,PLGA,PCL,SF,CS) 通过可调节的降解使药物释放时间延长.
- 纳入脂质体和聚合物纳米粒子/微粒可提高药物加载和释放时间.
- 不同的微针设计 (固体,涂层,溶解,空洞,形成水凝,可生物降解) 提供各种释放配置文件.
结论:
- 长期起作用的微针系统显示了通过皮肤递送药物的重大前景.
- 材料选择和先进的药物载体是实现持续释放的关键.
- 克服制造一致性,无菌性和体内验证方面的挑战对于临床采用至关重要.
相关概念视频
Drug Delivery: Miscellaneous Routes
705
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
705
Non-Oral Extravascular Drug Absorption Routes
479
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
479


