为控制释放和炎症应用开发带有阿托卡尔的奇托桑颗粒
Piyapan Manklinniam1, Phonchanok Reuk-Ngam2, Supavadee Boontha3
1Division of Microbiology and Parasitology, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.
Polymers
|January 10, 2026
概括
这项研究开发了带有关节素的奇托桑微粒 (CSPs/AE),用于增强抗炎作用. 这种新系统证明了显著的氧化减少,显示了骨关节炎管理的潜力.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 自然产品化学 自然产品化学
- 材料科学 材料科学 材料科学
背景情况:
- 阿尔托卡尔是来自*Artocarpus altilis*的一种黄,具有抗炎和老年保护性质.
- 为了提高阿托卡尔宾的稳定性和有效性,需要先进的输送系统.
- 基托微粒为药物输送提供了一个生物相容的平台.
研究的目的:
- 为了从 *Artocarpus altilis* 中心木中分离和描述 artocarpin.
- 开发和优化基托基的微粒,用于提供关节.
- 评价带有关节素的微粒的物理化学性质,体外释放和抗炎活性.
主要方法:
- 通过化和染色学净化分离阿尔托卡.
- 使用三聚酸交叉链接的奇托桑微粒配方.
- 使用HPLC,DLS,FTIR,XRD和体外释放研究进行表征.
- 在LPS刺激的RAW 264.7巨细胞中通过氧化抑制的抗炎活性的评估.
主要成果:
- 隔离的81%纯度的阿托卡;开发出稳定的基托桑微粒 (1-4μm) 具有良好的封装效率.
- FTIR和XRD证实了阿托卡因成功地被纳入基托基因组.
- 在体外研究表明,双相释放和显著,剂量依赖的氧化生产减少 (34.33-73.19%).
结论:
- 带有关节糖的奇托桑微粒 (CSP/AE) 是关节糖的一种有前途的输送系统.
- 开发的系统表现出有效的抗炎特性.
- 这种配方有可能用于管理炎症状况,如骨关节炎.
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