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电聚烯/碳纳米管膜用于通过皮肤输送药物系统

Elizabeth Ortiz-Maldonado¹, Eduardo San Martin-Martínez², Ningel Omar Gama-Castañeda²

¹Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Eduardo Monroy Cárdenas 2000, San Antonio Buenavista, Toluca de Lerdo 50110, Mexico.

|January 10, 2026

概括

这项研究开发了与生物相容的聚烯 (PCL) 纳米纤维膜,并用功能化的多壁碳纳米管 (f-MWCNTs) 增强,用于控制药物输送. 这些膜对透皮器件有前途,提高治疗效率和患者坚持治疗.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
聚合物化学聚合物化学

背景情况:

对慢性疾病治疗的不良坚持限制了治疗的有效性.
控制药物释放系统,如膜和贴片,提供了一个有希望的解决方案.
电纳米纤维膜为药物输送提供了一个多功能平台.

研究的目的:

设计和描述用功能化的多壁碳纳米管 (f-MWCNTs) 增强的电聚烯酸乙烯 (PCL) 纳米纤维膜.
评估这些复合膜在生物医学应用中的潜力,特别是通过皮肤递送药物系统.
评估开发的膜的生物相容性和机械性能.

主要方法:

聚卡普罗拉克 (PCL) 膜的电,含有不同度的功能化多壁碳纳米管 (f-MWCNTs).
使用扫描电子显微镜 (SEM),富里埃变换红外光谱 (FTIR),原子力显微镜 (AFM) 和动态机械分析 (DMA) 的表征.
使用外周血液单核细胞进行细胞毒性评估.

主要成果:

经过成功制造的直径小于100nm的纳米纤维,由于电旋膨胀而表现出微球内含.
光谱和机械分析证实了PCL矩阵和f-MWCNTs之间的分子相互作用.
生物测试表明,这些膜是生物相容的,f-MWCNT分散和纳米纤维尺寸都有助于这种特性.

结论:

开发的f-MWCNT增强的PCL纳米纤维膜具有生物相容性,并具有适合生物医学应用的特性.
这些膜显示出在先进的药物输送系统中使用的巨大潜力,特别是通过皮肤的应用.
这些发现支持使用这些复合膜来提高治疗疗效和患者在慢性疾病管理中的坚持.

关键词:

生物医学膜膜碳纳米管是如何使用的电力旋转是指电力旋转.膜膜膜膜膜膜膜聚卡普罗拉克托尼是一种多重的产物.

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