在重症监护室跟踪的肺癌患者的炎症相关参数
Burcu Tunay1, Omer Fatih Olmez2, Ahmet Bilici2
1Department of Anesthesiology and Reanimation, Istanbul Medipol University, Istanbul 34000, Turkey.
预后营养指数 (PNI),APACHE-II和死亡概率模型II-入院 (MPM II-入院) 有效预测重症监护室肺癌患者的死亡率,PNI显示独立关联.
科学领域:
- 在瘤学瘤学.
- 关键护理医学 关键护理医学
- 炎症研究 炎症研究
背景情况:
- 肺癌是癌症死亡的主要原因之一.
- 肺癌患者在ICU中的炎症标志物的预后价值尚未完全理解.
- 确定可靠的预后指标对于患者管理至关重要.
研究的目的:
- 评估和比较各种炎症标志物的预测性表现和重症监护室 (ICU) 肺癌患者死亡率的预后得分.
- 确定这些标志物是否独立地与死亡率相关.
主要方法:
- 分析了229名进入ICU的肺癌患者 (小细胞或非小细胞) 的队列.
- 评估的预后测试包括中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),淋巴细胞与单细胞的比率 (LMR),全身免疫炎症指数 (SII),修改的格拉斯哥预后得分 (mGPS),预后营养指数 (PNI),APACHE II得分和MPM II-Admission.
- 用多变量逻辑回归来确定死亡率的独立预测因素.
主要成果:
- 在229名患者中,有135人 (58.95%) 死亡,有94人 (41.05%) 退院.
- MPM II-Admission,APACHE II和mGPS显示出对死亡率预测的高度敏感性.
- 在MPM II-Admission,PNI和APACHE II中,它们的特异性很高.
- 预后营养指数 (PNI) 是唯一独立与死亡率相关的炎症相关标志物.
结论:
- PNI,APACHE-II和MPM II-Admission是估计肺癌ICU患者死亡风险的有价值,易于使用的工具.
- 普尼的独立协会强调其在预测这些患者的结果方面的重要性.
- 这些评分的进一步验证可能有助于肺癌重症监护机构的临床决策.
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