大麦叶通过肠道屏障和小鼠微生物群调节改善了洛帕胺诱导的便秘
Yuting Xu1, Zhiqian Wu1, Matthew Lee Cohoon1
1Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Foods (Basel, Switzerland)
|January 10, 2026
概括
大麦叶 (BL) 在预防便秘方面表现有前途. 常见大麦叶 (CBLs) 和无大麦叶 (HBLs) 均改善了小鼠的肠道通道和便产量,表明它们作为功能性食物的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 营养科学 营养科学
背景情况:
- 便秘是一种普遍的胃肠道疾病,影响生活质量并导致并发症.
- 大麦叶 (BLs) 被探索为功能性食品,用于预防便秘.
- 了解普通大麦叶 (CBLs) 和无大麦叶 (HBLs) 的特定影响至关重要.
研究的目的:
- 在小鼠模型中研究CBL和HBL对洛佩拉胺诱导的便秘的预防作用.
- 阐明潜在的机制,包括肠道运动,激素调节,基因表达和微生物群的变化.
主要方法:
- 在C57BL/6小鼠中使用了洛佩拉胺诱导的便秘模型.
- 在不同剂量中服用CBL和HBL.
- 评估便参数,胃肠道过渡,肠道运动激素,结肠基因表达 (AQP3,AQP4,5-HT4R,SERT),短链脂肪酸 (SCFA) 和肠道微生物群组成.
主要成果:
- 这两种BL都显著改善了便参数和胃肠道通行.
- 高剂量的HBL显著增加了便重量和颗粒数量.
- BLs调节了肠道运动激素,使关键基因表达正常化,增强了SCFA的产生,并改变了肠道微生物群 (增加了Bacteroides,减少了Akkermansia).
- 观察到不同的机制:CBLs影响了SERT表达,而HBLs独特地增加了SCFA产量并减少了Alistipes.
结论:
- 大麦叶 (CBL和HBL) 显示出对小鼠的洛佩拉胺诱导便秘的预防作用.
- 机制包括调节肠道屏障功能,肠道运动激素和肠道微生物群组成.
- 需要进一步的研究来确定活性成分,并在人类临床研究中验证疗效.
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