慢性肺炎和心血管疾病:生物标志物引导的分层和治疗前景
Melika Valizadeh1, Jens-Ulrik Jensen2,3, Alexandr Ceasovschih4
1Pulmonary Rehabilitation Research Center (PRRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran 19839-63113, Iran.
慢性阻塞性肺病 (COPD) 显著增加了心血管疾病 (CVD) 的风险. 本综述探讨了这些相互关联的疾病的早期检测和个性化治疗的共享机制和生物标志物.
科学领域:
- 肺和心血管医学 肺和心血管医学
- 生物标志物发现发现
- 翻译研究是翻译研究.
背景情况:
- 慢性阻塞性肺病 (COPD) 是心血管疾病 (CVD) 的主要危险因素,包括心力衰竭,心律失常和肺高血压.
- 慢性肺炎和心血管疾病之间的关系是双向的,每一种疾病都会对另一种疾病的预后产生负面影响.
- 共同的风险因素 (吸烟,衰老) 和COPD特异性机制 (炎症,缺氧) 导致心血管疾病发病率和死亡率.
研究的目的:
- 审查COPD和心血管疾病之间的病理生理联系.
- 突出用于风险分层和预后的新型循环生物标志物.
- 讨论生物标志物引导的个性化治疗策略的含义.
主要方法:
- 关于病理生理机制的综合文献综述.
- 对新兴生物标志物的现有证据的分析.
- 临床和研究影响的综合.
主要成果:
- 慢性肺炎独立地通过全身炎症,氧化应激,缺氧和高通胀导致心血管疾病.
- 几种循环生物标志物显示出预测COPD患者主要心血管不良事件 (MACE) 和全因死亡率的潜力.
- 生物标志物发现对于早期检测和风险分层至关重要.
结论:
- 了解COPD-CVD联系对于患者的治疗结果至关重要.
- 新兴的生物标志物为个性化医疗方法提供了希望.
- 以生物标志物为指导的策略可以优化伴随性COPD和CVD患者的治疗.
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