益生菌对椎病临床结果的影响:系统性审查和元分析
Jawad S Alnajjar1, Norah I Alabdullatif1, Mohemed AlBohassan1
1College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Journal of clinical medicine
|January 10, 2026
概括
益生菌可以改善症状,并减少分歧性疾病 (DD) 中的炎症. 长时间使用多菌株益生菌有希望,但需要更多的研究来证实对DD管理的好处.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 营养科学 营养科学
背景情况:
- 转性疾病 (DD) 在老年人群中很常见,并且与肠道失调有关.
- 益生菌被探索为DD症状和炎症管理的辅助疗法.
- 目前关于益生菌对DD的疗效的证据是不确定的.
研究的目的:
- 系统地审查关于益生菌在管理分歧性疾病中的使用证据.
- 评估益生菌对DD患者症状,炎症和复发的影响.
主要方法:
- 在主要数据库中进行了全面的文献搜索,截至2024年10月.
- 包括随机对照试验 (RCT) 和成人DD患者益生菌的观察性研究.
- 对症状和复发数据使用了元分析;CRP结果被描述性地总结.
主要成果:
- 益生菌治疗显著改善了腹痛 (SMD 0.63).
- 观察到不显著的膨胀改善趋势 (SMD 0.158).
- 通过多菌株,持续时间较长的益生菌,发现复发风险降低 (RR 0.22);观察到CRP减少,但没有聚合.
结论:
- 长期使用多菌株益生菌可以缓解DD症状并减少炎症.
- 由于研究异质性和局限性,证据确定性低至非常低.
- 需要高质量的RCT来确定最终的临床影响和DD中益生菌的最佳使用.
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