在ADHD中与月经周期相关的荷尔蒙波动:对认知功能的影响 - - 一篇叙事评论
Dora Wynchank1, Regina M G T M F Sutrisno1,2, Emma van Andel1
1Expertise Center Adult ADHD, PsyQ, Parnassia Group, Carel Reinierszkade 197, 2593 HR The Hague, The Netherlands.
患有多动症的女性在月经周期期间会经历认知波动,特别是在状期,注意力和执行功能会恶化. 这些变化影响了日常生活和治疗的有效性,需要进一步研究量身定制的策略.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种影响认知和多巴胺的神经发育障碍.
- 患有ADHD的女性报告了与荷尔蒙有关的困难,月经周期的变化影响了情绪,认知和治疗疗效.
研究的目的:
- 审查月经周期荷尔蒙波动对女性认知功能和多动症症状的影响.
- 综合当前关于激素变化如何影响月经周期内的注意力,执行功能和冲动性的证据.
主要方法:
- 在Ovid EmBase上对2015年至2025年间发表的研究进行了全面的文献搜索.
- 包括的研究检查了有或没有ADHD的女性在月经周期各个阶段的认知表现,利用神经生物学测量.
主要成果:
- 临床前的人群在中期的乳房期表现出更强的注意力,这可能与孕激素有关.
- 患有多动症和/或情绪障碍的女性在月经期中期和月经前期表现出注意力,执行功能和冲动性受损.
- 这些客观发现与主观报告的认知恶化和药物效率下降的情况一致.
结论:
- 与ADHD相关的认知功能随月经周期而变化,ADHD和伴随性情绪障碍的女性的障碍最为明显.
- 潜在的机制包括对阿洛普雷格纳诺和雌激素戒断的高度敏感性.
- 进一步的研究对于临床应用至关重要,包括针对女性的诊断和治疗.
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