持续的正气道压力可以改善阻塞性睡眠呼吸暂停的MASLD患者的肝脏结果吗? 一个系统的审查
Theja V Channapragada1, Clinton R Brenner2, Keven Guruswamy3
1Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Journal of clinical medicine
|January 10, 2026
概括
持续的正气压 (CPAP) 在阻塞性睡眠呼吸暂停 (OSA) 患者的代谢功能障碍相关的脂肪性肝病 (MASLD) 中提供了有限的益处,显示肝酶和代谢标记的轻微改善,但没有脂肪症或纤维化.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 睡眠医学 睡眠医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 经常与阻塞性睡眠呼吸暂停 (OSA) 一起发生.
- 重叠的代谢风险因素有助于MASLD和OSA的高并发症.
- 持续正气道压力 (CPAP) 对OSA的MASLD患者肝脏结果的影响尚未得到充分证实.
研究的目的:
- 系统地审查OSA治疗对MASLD患者肝脏和代谢结果的影响.
- 评估CPAP和其他干预措施在管理MASLD和相关代谢参数方面的有效性.
主要方法:
- 随机对照试验 (RCT) 和观察性研究的系统审查.
- 在PubMed,Web of Science和CINAHL搜索了有关患有MASLD和OSA的成年人的研究.
- 评估肝硬度,脂肪含量,酶,纤维化,HbA1c,脂质,人体测量和偏差风险.
主要成果:
- 包括8项研究 (3项RCT,5项观察性) 涉及1006名参与者.
- CPAP显示肝酶 (ALT,AST) 的适度,不一致的减少以及HbA1c和甘油三的微小改善.
- 在整个研究中,肝硬度,肥胖症,纤维化或身体组成没有显著改善.
结论:
- 在患有OSA的MASLD患者中,CPAP可能对肝酶和某些代谢标志物提供边际益处.
- 支持CPAP在改善肝硬化症,纤维化或身体组成方面的疗效的证据有限.
- 证据的确定性较低,需要高质量的纵向试验,以澄清CPAP在MASLD管理中的作用.
关键词:
在CPAP中使用CPAP.马斯尔德 马斯尔德是什么意思在OSA中使用OSA.持续的正气道压力持续的正气道压力与代谢功能障碍相关的脂肪性肝病.阻塞性睡眠呼吸暂停 (SOP) 的情况.系统性审查 系统性审查更多相关视频
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