血清S100B蛋白对心脏骤停后神经结果的预后价值:系统性审查和元分析
Łukasz Szpinda1, Michal Lis2,3, Michal Pruc4
1Department of Anaesthesiology and Intensive Care, Czerniakowski Hospital, 00-739 Warsaw, Poland.
Journal of clinical medicine
|January 10, 2026
概括
血清S100B蛋白水平可靠地预测心脏骤停 (CA) 后的神经结果. 较低的S100B度表明良好的恢复,有助于关键的复苏后护理决策.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 关键护理医学 关键护理医学
背景情况:
- 心脏骤停 (CA) 是导致死亡和残疾的主要原因.
- 在治疗指导方面,早期神经学预后对CA后至关重要.
- 蛋白质S100B是脑损伤的潜在生物标志物.
研究的目的:
- 系统地审查和元分析血清S100B的预后和诊断准确性,以确定CA后的神经结果.
- 评估S100B在预测心脏骤停后患者康复方面的有效性.
主要方法:
- 40项观察性研究的系统综述和元分析.
- 在主要数据库 (PubMed,Embase,Scopus,Web of Science,CENTRAL,CINAHL) 进行的搜索截至2025年11月.
- 用于聚合分析的随机效应模型.
主要成果:
- 与不良的神经结果相比,在神经结果有利的患者中发现S100B水平明显较低 (SMD-1.78).
- 观察到高诊断准确度:聚合灵敏度为0.63,特异性为0.93,AUC为0.89.
- 亚组和灵敏度分析证实了这些发现,出版偏差最小.
结论:
- 血清S100B是一种可靠的早期生物标志物,用于心脏骤停后的神经预后.
- 将S100B集成到多式预后工具中可以改善复苏后护理决策.
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