相关实验视频

Updated: Jan 13, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

在儿童患者中区分简单和复杂尾炎的CLR (CRP到淋巴细胞) 评分

Adir Alper¹, Ariel Galor¹, Mathias Lerner¹

¹Shamir Medical Center, Be'er Ya'acov 60930, Israel.

Journal of clinical medicine

|January 10, 2026

概括

在儿童中,C-反应性蛋白与淋巴细胞比率 (CLR) 有效地区分了复杂的和简单的尾炎. 这种生物标志物为儿科外科紧急情况提供了一个有希望的,易于使用的工具,特别是在资源有限的环境中.

科学领域:

儿科手术儿科手术
生物标志物发现发现
炎症标记物炎症标记物

背景情况:

急性尾炎是一种常见的儿科手术紧急情况.
区分简单和复杂的尾炎对于治疗至关重要.
现有的诊断工具,如临床分数和超声波,都有局限性.

研究的目的:

评估几种基于炎症的生物标志物的疗效,以区分儿科患者的简单尾炎 (SA) 与复杂尾炎 (CA).
为了比较中性粒细胞与淋巴细胞比率 (NLR),单细胞与淋巴细胞比率 (MLR),血小板与淋巴细胞比率 (PLR),中性粒细胞与单细胞比率 (NMR),中性粒细胞与血小板比率 (NPR),泛免疫炎症值 (PIV) 比率和C-反应蛋白与淋巴细胞比率 (CLR) 的诊断准确度.

主要方法:

对878名经过尾切除术的儿科患者 (<18岁) 的回顾性分析.
根据手术内发现,尾炎被分类为简单 (SA) 或复杂 (CA).
使用手术前的血液样本和C-反应蛋白 (CRP) 水平来计算生物标志物比率;使用ROC曲线评估诊断准确性.

主要成果:

与简单尾炎 (SA) 相比,复杂尾炎 (CA) 患者的中性粒细胞,单细胞,血小板数量和CRP水平显著增加.
所有评估的生物标志物比率,包括NLR,MLR,PLR,NMR,NPR,PIV和CLR,在CA患者中显著升高 (p <0.01).
"C-反应蛋白与淋巴细胞比率 (CLR) 显示出最高的诊断准确度 (AUC = 0.772),超过其他生物标志物,其次是PIV (AUC = 0.679).

结论:

CLR是一种高度准确和有前途的生物标志物,用于区分儿科人口中简单和复杂的尾炎.
CLR提供了潜在的有价值和可访问的诊断辅助,特别有利于资源有限的医疗保健机构.
需要进一步的前性研究来验证CLR在儿科尾炎管理中的临床实用性.

关键词:

在CLRR中,CLR是最重要的.血清蛋白与淋巴细胞的比率.在MLR中,MLR是MLR.在NLR中,它是NLR.在 PIVIV 中.在PLR PLR中,急性尾炎是什么情况生物标志物生物标志物复杂的尾炎是什么

更多相关视频

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

相关概念视频

Appendicitis-II: Diagnostic Studies and Management

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...

Appendicitis-I: Introduction

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...