通过生物信息学探索由动脉样硬化复杂的非酒精性脂肪肝疾病的病原性
Rui Yan1, Ping Li, Jiahui Song
1Department of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Medicine
|January 10, 2026
概括
这项研究确定了动脉样硬化和非酒精性脂肪肝疾病之间的45个共同基因,揭示了这些相互关联的疾病的共同途径和潜在的治疗点.
科学领域:
- 心血管生物学 心血管生物学
- 肝病学 肝病学是一种肝病学.
- 生物信息学是一种生物信息学.
背景情况:
- 动脉样硬化 (AS) 和非酒精性脂肪肝 (NAFLD) 是普遍存在的慢性疾病.
- 无论是AS还是NAFLD,都具有共同的风险因素和病理特征.
- 了解共同的分子机制对于有效的治疗策略至关重要.
研究的目的:
- 为了确定AS和NAFLD之间的共同差异表达基因 (DEGs).
- 探索这些共享的DEGs的潜在生物功能和信号通路.
- 确定两种疾病的潜在诊断生物标志物和治疗点.
主要方法:
- 利用了基因表达综合 (GEO) 数据库中的公开数据集 (GSE89632,GSE100927) 的生物信息学分析.
- 进行了差异基因表达分析,基因组丰富分析 (GSEA),基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 路径分析.
- 构建了一个蛋白质-蛋白质相互作用 (PPI) 网络以识别枢纽基因,并使用接收器操作特征 (ROC) 曲线分析评估它们的诊断价值.
主要成果:
- 在AS和NAFLD之间确定了45种常见的DEG.
- GSEA揭示了这两种情况之间的共同路径.
- GO和KEGG分析表明,细胞因子生产,外部刺激反应和巨细胞激活的丰富性,其中关键途径包括细胞因子-细胞因子受体相互作用,类似收费的受体信号传递和IL-17信号传递.
- 十个枢纽基因 (OSM,IL1B,CCL3,CSF3,IL1RN,TAGLN,CNN1,RGCC,MYH11,ACTG2) 被发现具有诊断潜力.
结论:
- 在AS和NAFLD之间存在共同的DEG和途径,表明相互影响和恶化.
- 共享的致病机制为预防NAFLD患者的AS提供了潜在的治疗点.
- 这些发现有助于更深入地了解代谢和心血管疾病的相互联系.
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