消费不同类型的茶叶与中风风险之间的因果关系:双样本孟德尔随机化分析
Xutang Jiang1,2, Qingxin Lin1,2, Wen Gao1,2,3
1Department of Neurosurgery, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian Province, China.
Medicine
|January 10, 2026
概括
基因预测的红茶摄入量可能会因果性地降低大动脉动脉样硬化中风 (LAAS) 和心血管栓塞性中风 (CES) 的风险. 这项门德尔的随机化研究提供了茶饮食的证据.
科学领域:
- 遗传学 遗传学 是一个
- 流行病学 流行病学
- 心血管疾病研究研究
背景情况:
- 茶饮是一种全球性的习惯,但其与各种类型的中风的因果关系尚不清楚.
- 以前的观察性研究受到混因素和潜在偏差的限制.
- 遗传预测提供了一种方法来调查观测数据中的因果关系.
研究的目的:
- 研究遗传预测茶饮与七种不同类型中风风险之间的因果关系.
- 使用孟德尔随机化区分各种茶类对中风风险的影响.
主要方法:
- 采用双样本门德尔随机化 (MR) 分析,包括单变量和多变量方法 (MVMR).
- 利用了来自大型队列的茶饮和中风结果的全基因组关联研究 (GWAS) 数据.
- 选择了1061个单核酸多态 (SNPs) 作为七种中风类型的仪器变量.
主要成果:
- 统一的MR显示了红茶摄入量与大动脉动脉样硬化中风 (LAAS),小血管中风,缺口中风和心血管栓塞性中风 (CES) 的风险增加之间的潜在关联.
- 多变量MR分析,在考虑到潜在的性质后,揭示了红茶摄入量与LAAS (OR=0.942) 和CES (OR=0.952) 风险降低之间的显著因果关系.
- 在MVMR分析中没有检测到显著的水平性,这支持了研究结果的稳定性.
结论:
- 这项研究提供了强有力的证据,证明了基因预测的红茶消费与特定中风亚型 (即LAAS和CES) 的风险降低之间的因果关系.
- 这些发现表明,红茶的摄入可能对某些类型的中风有保护作用.
- 需要进一步的研究来探索这种关联背后的生物机制.
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