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研究与肥胖相关的特征与大脑健康之间的多维关联,并确定潜在的机制
Shuyuan Chen1, Jie Wen2,3, Zeming Tan2,3
1Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Medicine
|January 10, 2026
概括
通过体质指数 (BMI),腰围 (WC) 和腰比 (WHR) 测量的肥胖症因果上会增加中风风险,并对认知功能和大脑结构产生负面影响. 控制肥胖对于保持大脑健康至关重要.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 肥胖和大脑健康之间的关系,包括脑血管疾病,认知和神经解剖学,尚未完全理解.
- 肥胖是一个日益严重的全球健康问题,可能会产生深远的后果.
研究的目的:
- 为了研究肥胖特征对各种大脑健康结果的因果关系,使用双样本的门德尔随机化方法.
- 通过全转录组关联研究 (TWAS) 探索可能调解这些效应的生物途径.
主要方法:
- 采用双样本孟德尔随机化 (MR) 评估肥胖度 (BMI,WC,WHR) 和大脑健康结果 (中风,流体智力,脑成像表型) 之间的因果关系.
- 进行了全转录组关联研究 (TWAS),以确定生物途径.
- 协会在国家健康和营养检查调查 (NHANES) 中使用后勤回归进一步检查.
主要成果:
- 较高的BMI,WC和WHR显著与中风风险增加有关 (例如,BMI OR=1.18).
- 增加的BMI和WHR与较低的流体智力得分有关 (例如,BMI β=-0.21).
- 体重指数 (BMI) 证明了对7个脑图像衍生的表型的因果关系,而TWAS涉及代谢,免疫和表观遗传途径.
结论:
- 肥胖,特别是BMI升高,对中风风险,认知功能和大脑结构有因果影响.
- 代谢,免疫和表观遗传途径可能是肥胖对大脑健康不利影响的媒介.
- 有效的肥胖预防和管理策略对于维持和改善大脑健康至关重要.
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